可乐定控释贴治疗儿童抽动障碍临床探究.docVIP

可乐定控释贴治疗儿童抽动障碍临床探究 　 作者： 张红宇，林 悦，刘美娜，邹小兵 【关键词】 可乐定控释贴;抽动障碍;儿童 摘要］目的: 探讨可乐定控释贴治疗儿童抽动障碍的临床疗效。 方法: 92例TICS患儿随机分为研究组25例（予可乐定控释贴治疗）、氟哌啶醇组38例（予氟哌啶醇治疗）和泰必利组29例（予泰必利治疗），采用耶鲁抽动症整体严重度量表（YGTSS）评分并记录治疗中可能出现的不良反应，共治疗12周。 结果: 治疗第12周末研究组有效率为84.0%，氟哌啶醇组为68.4%，泰必利组为65.5%（P均gt;0.05）;不良反应较轻且发生率（16.0%）明显低于氟哌啶醇组（65.8%）（Plt;0.01）和泰必利组（48.3%）（Plt;0.05）;平均显效时间研究组（45.65±8.57）d与氟哌啶醇组（40.81±6.79）d和泰必利组（42.34±7.92）d相当（P均gt;0.05）;研究组YGTSS总分减分率（64.90±10.49）%高于氟哌啶醇组（42.73±11.90）%和泰必利组（40.63±13.58）%（P均lt;0.05）。 结论: 可乐定控释贴治疗抽动障碍疗效优于氟哌啶醇和泰必利，不良反应较轻且发生率低。 　　关键词］ 可乐定控释贴;抽动障碍;儿童 Clonidine skin paster versus haloperidol and tiapride in the treatment of children with Tourette’s syndrome ［Abstract］Objective:To evaluate the efficacy and tolerability of clonidine skin paster in comparison with haloperidol and tiapride in the treatment of children with Tourette’s syndrome（TS）.Methods:Total92TS patients were divided into study group of25cases（treated with clonidine skin paster），haloperidol group of38cases（treated with haloperidol）and tiapride group of29cases（treated with tiapride），and the period of treatment was12weeks.All the cases were scored by the Yale Global Tic Severity Scale（YGTSS），and there were no significant difference in YGTSS scores between three groups at the beginning of the study.Results:The proportion of efficacious cases in clonidine skin paster group（84.0%）appeared slightly higher than that in haloperidol group（68.4%，Pgt;0.05）and tiapride group（65.5%，Pgt;0.05）;the proportion of side effects in study group（16.0%）was significant lower than that in haloperidol group（65.8%，Plt;0.01）and tiapride group（48.3%，Plt;0.05）;there was no difference in mean remission time between three groups（45.65±8.57）d，（40.81±6.79）d and（42.34±7.92）d respectively（Pgt;0.05）.Clonidine skin paster produced a higher reduction in the YGTSS（64.90±10.49）%than haloperidol（42.73±11.90）%（Plt;0.05）and tia-pride（40.63±13.58）%（Plt;0.05）.Conclusions:In this pilot study，clonidine skin paster was demonstrated a better efficacy th