正常人闪光视网膜电图特征.docVIP

正常人闪光视网膜电图特征 　【摘要】 　　目的：探讨闪光视网膜电图（flash electroretinogram , F-ERG）在正常人的变化规律，以获得正常参考值。方法：应用法国Metrovision 公司生产的Vision Monitor 视觉诱发系统检测正常人53例73眼。F-ERG的5个标准反应，包括暗适应25dB弱光刺激时的反应（来自于视杆细胞）、暗适应0dB强光刺激时的反应、振荡电位、明适应白色标准闪光刺激时的反应（来自于视锥细胞）和明适应快速重复闪烁光刺激的反应。按照10岁为一年龄组分成4组：20～29岁，20眼；30～39岁，22眼；40～49岁，19眼；50～60岁，12眼。比较4个年龄组振荡电位总振幅和a波、b波的振幅及潜伏期。 结果：F-ERG暗适应25dB弱光刺激时a波无明显反应，b波潜伏期为110.2±11.3ms，振幅为226.7±49.2μV；暗适应0dB强光刺激时a波潜伏期为26.3±1.2ms，振幅为-205.4±40.1μV，b波潜伏期为49.3±2.3ms，振幅为481.2±81.2μV；明适应白色标准闪光刺激时a波潜伏期为23.0±1.6ms，振幅为 -23.4±9.1μV，b波潜伏期为38.8±1.8ms，振幅为77.4±21.2μV；明适应快速重复闪烁光刺激b波的振幅为122.1±27.5μV；震荡电位总振幅为112.6±28.2μV。随着年龄的增加，振荡电位总振幅和其余4个标准反应的b波振幅逐渐降低，a波振幅与年龄的增加无明显相关性，50～60岁年龄组a、b波的潜伏期较其他组延长，但各年龄组两两比较无显著统计学差异（P ＞0.05）。结论：确定了正常人F-ERG的5个标准反应的正常值，并比较了振荡电位总振幅和a，b波振幅及潜伏期与年龄的关系，振荡电位总振幅和b波振幅随着年龄的增加逐渐降低，a波振幅与年龄的增加无明显相关性，50～60岁年龄组a，b波的潜伏期较其他组延长，但各年龄组两两比较无显著统计学差异（P ＞0.05）。 【关键词】 正常人　视网膜电图　振荡电位 　　Spatial characteristics of flash electroretinogram in normal subjects Abstract AIM: To study the characteristics of Flash Electroretinogram (F-ERG) in normal subjects so as to obtain normal reference values.METHODS: By using Vision Monitor visual evoked response imaging system, the standards for five obtained Flash Electroretinogram (F-ERG) were recorded on 53 normal subjects (73 eyes), including F-ERG to a weak flash (arising from the rods) in the dark-adapted eye，F-ERG to a strong flash in the dark-adapted eye, oscillatory potentials, F-ERG to a strong flash (arising from the cones) in the light-adapted eye, and F-ERGs to a rapidly repeated stimulus (flicker). The data were divided into 4 groups by age: 20-29 years old, 20 eyes; 30-39 years old, 22 eyes; 40-49 years old, 19 eyes; 50-60 years old, 12 eyes. The sum amplitude of oscillatory potential , the amplitudes and implicit time of a wave and b wave with 4 groups were analyzed. RESULTS: F-ERG to a weak flash (arising from the rods): a wave was no obvious, the implicit time of b wave was 110.2±11.3 ms, the amplitude of b wave was 226.7±49.2μV;F-ERG to a