氟西汀联合心理干预治疗抑郁障碍临床探究.docVIP

氟西汀联合心理干预治疗抑郁障碍临床探究 　 作者：邓映霞 谢惠兰 周泽慧 【关键词】 抑郁障碍；心理治疗；氟西汀；汉密顿抑郁量表；汉密顿焦虑量表 　　【摘要】 目的 探讨氟西汀联合心理干预治疗抑郁障碍的临床疗效。 方法 将62例抑郁障碍患者随机分为研究组32例，对照组30例。两组均给予氟西汀治疗。在药物治疗的基础上，研究组联合心理治疗。8 w疗程结束后，两组均进行门诊随访1次#12539;mo-1，共6 mo，观察复发情况。治疗前与治疗第8 w末采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效。 结果 治疗8 w末研究组总有效率93.75%，对照组73.33%，两组间比较差异有显著性（χ2=4.77，P＜0.05）；两组治疗8 w末汉密顿抑郁量表、汉密顿焦虑量表评分均较治疗前有极显著性下降（Plt;0.01），研究组较对照组下降更显著（Plt;0.01）。随访6 mo末研究组复发率显著低于对照组（χ2=6.67，P＜0.01）。 结论 氟西汀联合心理干预治疗抑郁障碍较单纯药物治疗疗效显著。 　　【关键词】 抑郁障碍；心理治疗；氟西汀；汉密顿抑郁量表；汉密顿焦虑量表 　　A clinical study of fluoxetine combined with psychological intervention in treatment of depressive disorder 　　【Abstract】 Objective To explore the curative effect of floxetine combined with psychological intervention in depressive disorder.Methods Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) were carried out in 62 patients with depressive disorder. They were divided randomly into 2 groups: the study group (n＝32) received both floxetine and psychotherapy, while the control group (n＝30) only received drug therapy. After 8 weeks, the therapeutic effects were evaluated. Results Compared with protreatment, significant difference was found in both groups posttreatment (P＜0.01). The levels of anxiety and depression were reduced. The scores of HAMD and HAMA in the study group were significantly lower than those in the control group (P＜0.01). After 8 weeks of treatment, the total effective rate of the study group was higher than that of the control group (P＜0.05). The recurrence rate of study group was obvious lower than that of control group at the 6 months of followup. Conclusion Psychological intervention combined with drug therapy is more effective than simple drug therapy in depressive disorder. 　　【Keywords】 Depressive disorder；psychotherapy；floxetine；the HAMD；the HAMA 　　抑郁障碍是一种以心境低落为主的严重危害身心健康的常见疾病，症状反复发作，迁延不愈，严重者可出现木僵、幻觉、妄想等精神症状。目前临床上仍以药物治疗为主，为此作者在应用药物治疗的基础上联合了心理治疗方法，以探讨心理治疗的临床效果，现将结果报告如下。 　　1 对象与方法 　　1.1 对象 选取湖南省湘潭市第五人民医院心理科住院治疗的抑郁障碍患者为研究对象。入组标准：