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Effectsof onthe
and ofhumanovariancarcinoma
growthangiogenesis
… ●
in
nutemice
xenogralts
A。BSTRACT
the of
effects
Objective:Toinvestigate
the ofhuman c缸cmoma innudemice
(ADFMChR)ongrowth ovarian xenografts
anditsmechanism
Methods:Modelofhumanovarian innude
micewas dividedinto5
established,andgroups:control
dose dose
low ADFMChR(1
ADFMChR(6mg/kg)group,medium8mg/kg)group
and dose volumeand were
hi.gh ADFMChR(54mg/kg)group.Tumorweight
measured.Theserumlevelsof andCREaswellaswhitebloodcell
AST,ALT.LDH
ofhumanovariancarcinoma
countsweredetermined.Therateof cells
apoptotic
was PIstainedflow
xenograftanalyzedby
in toobserve
subcutaneouswasfabricatedinto waxslicesorder
xenograft paraffin
the of under SP
xenograft microscope.
pathologicalmorphoMgy
method to the ofvascular
immunohistochemicalwasused analyzeexpression
endothelial cellnuclear
growth
factor(VEGF),proliferating
Plateletendothelialcelladhesion humanovarian
molecule—I(PECAM一1,CD31)in
CanCer
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