不同化疗方案治疗肺结核合并慢性乙型肝炎患者的疗效及对肝功能的影响.pdfVIP

吉林医学2017年3 月第38卷第3 期 • 435 • 不同化疗方案治疗肺结核合并慢性乙型肝炎患者的疗效 及对肝功能的影响 王育强,刘 送 妹 （广东省梅州市人民医院，广 东 梅 州 514000) [ 摘 要 ] 目的：对 比2HRZE/4H R 与 3HESG/9HEG 方案对肺结核合并慢性乙型肝炎（慢性乙肝）的治疗效果及对 肝功能的影响。方 法 :择 取肺结核合并慢性乙肝患者 88例 ，以 随 机 数 字 表 法 分 组 ，每 组 各 有 44 例 ，A 组 接 受 2HRZE/ 4H R 方案治疗，B 组 接 受 2HTES (LfX )/4 -7HTE 方案治疗。结 果 ：与 A 组 相比，B 组的治疗总有效率、病灶吸收率、痰菌 转阴率、空洞缩小及闭合率均显著升高，肝损害及不良反应发生率均明显降低，肝功能各项指标均显著改善，组 间 比 较 ， 差异有统计学意义 P 〇.〇5。结论:与 2HRZE/4H R 方案相比 ,2HTES (LfX )/4 -7HTE 方案对于肺结核合并慢性乙肝患 者效果更佳，更利于肝功能的修复,故应予推广。 [关 键 词 ]肺结核;慢性乙型肝炎;化疗方案；疗效;肝功能 Effect of different chemotherapy regimens in the treatment of pulmonary tuberculosis complicated with chronic hepatitis B WANG Yun - qiang,LIU Song-m ei ( The Peoples Hospital of Meizhou City, Guangdong Province, Meizhou 514000, China ) Abstract ： Objective To compare the treatment effect of 2HRZE/4HR and 3HESG/9HEG regimens in the treatment of pul ­ monary tuberculosis complicated with chronic hepatitis B ( chronic hepatitis B ) and its influence on live function . Method 88 patients with pulmonary tuberculosis complicated with chronic hepatitis B were selected , and they were divided by the random dig ­ ital table method ,44 patients in each group . In the A group were received 2HRZE/4HR treatment,while in the B group were re ­ ceived 2 HTES (LfX ) /4 -7HTE program treatment . Results Compared with A group , the total efficiency of the treatment , lesion absorption rate,the sputum negative conversion rate , and reduce the cavity closure rate in the B group were significantly in ­ creased ,and the incidence rate of live damage and adverse reaction were significantly lowe , the the indexes of live function were significantly improved , and the comparison between groups , the differnce was statistically significant ( P 0.05 ) . Conclusion Compared with the 2HRZE/4HR regimen,the effect of 2HTES (LfX ) /4