服药时间（Taking time）.docVIP

服药时间（Taking time） Summary of taking time 2.1.1 take the medicine at night (1) the mechanism of statin lipid-lowering drugs is to inhibit the hydroxymethyl coenzyme two reductase (A) reductase, thereby inhibiting the synthesis of endogenous cholesterol. Since cholesterol is mainly synthesized at night, it is more effective at night than during the day. Common drugs are simvastatin, rosuvastatin, atorvastatin, and so on. In (2) anti asthma drugs for asthma at night, early morning to attack, so once daily administration of anti asthma take half an hour before going to bed until midnight, when the highest blood drug concentration, good curative effect, can play a preventive role. Commonly used drugs include: Theophylline Sustained-release Tablets, long-acting beta 2 agonists (bambuterol and Bin Castro), a leukotriene receptor antagonist (montelukast pl). In (3) to treat constipation laxatives such as phenolphthalein, liquid paraffin, medication 8 ~ 10h after work, are required to take the next morning before going to bed half, defecation, physiological habit of human body. In (4) hypnotic effect quickly, such as chloral hydrate, need to take at bedtime; slow onset, such as benzene two nitrogen Zhuo, need to take half an hour before going to bed. In (5) drug effects on the blood vessels of the brain (such as flunarizine etc.), drugs are drowsiness side effects (such as anti allergic drug ketotifen, etc.) are required to take half an hour before going to bed. In addition, antirheumatic drugs such as nabumetone, evening medication efficacy can be kept overnight, also helps to prevent stiffness. Alpha receptor blocker terazosin should also be taken before bedtime so as to avoid orthostatic hypotension. In 2.1.2 take morning medication (1) glucocorticoids due to glucocorticoid secretion showed circadian change, secretion peak in the morning from 7 to 8, therefore, a day in the morning from 7 to 8 of the dose taking inhibitory effect of drugs on hypothalamic pituitary adrenal