碘海醇注射液（Iohexol Injection）.docVIP

碘海醇注射液（Iohexol Injection） Iohexol Injection (Iohexol Injection) (Parker) The main ingredients of this product and its chemical name are iodine alcohol, N, N- bis (2,3 - two - hydroxy - propyl) - 5 - [N - (2,3 - two - hydroxyl - propyl) - acetyl -] - 2,4,6 - three, iodine, -1,3-, benzene, two formamide. [traits] This product is colorless to light yellow transparent liquid. This product is a nonionic water-soluble contrast agent containing three iodine atoms, with a iodine content of 46.4%. It is readily available in sterilized aqueous solutions, and has different iodine concentrations, which are 140, 180, 240, 300, or 350mg iodine per milliliter concentration, respectively. [pharmacology and toxicology] Pharmacological action: This product is X, light and CT examination, commonly used contrast agents, can be used in the blood vessel, vertebral canal and body cavity. The result of animal test showed that the product had enhanced effect on liver, abdominal aorta and CT scan images in dogs. Toxicological effects: Proteinuria occurs in canine renal arteriography. [pharmacokinetics] By intravenous injection of iodine into the body, almost all the drugs were excreted in the urine in 24 hours. One hour after injection, urine concentrations were highest. No metabolite production. The hemodynamic parameters, clinical chemical parameters and coagulation parameters of the healthy volunteers receiving intravenous intravenous injection of iodine were very different from those before the injection, and the changes were not clinically significant. In rats, rabbits and dogs for intravenous injection is mainly excreted in the urine, a small part (5% rats, 1% dogs) discharged from the feces, have not yet found any organ absorption phenomenon, nor in the animal to detect any metabolites. The protein binding rate of this product is less than 2% or almost no binding to protein. [indications] The clinical applications of this product to adults and children urography and angiography, 1 ves