海马NMDA受体对严重烫伤HPA轴兴奋性影响及其机制的研究.pdf

Effetsof NMDA onHPA hippocampal axis receptor afterburnandits activity relatedmechanisms Abstract The first of toseveretraumaisstress theaim body response response，and is to ofit to theresistancetheattackandresumethe in strengthen turbulence the attackofseveretraumais thatthe is the so stress body．But suong usually indisorder．Themaincharacterofstressdisorderisoverexcitationof axis(HPA could an axis)whichplayimportant hypothalamo—pituitary-adrenal in and of role the ignitiondevelopmentsystemicinflammatoryresponse organ syndrom(SIRS)andmultipledysfunction resultedfromimmune itis to themechanisms inhibition，SO importantexplore the severe andcontrolover ofoverexcitationofHPAaxis trauma following excitationofHPAaxis are tobethe brain that Because consideredprominentregions hippocamus HPAaxis stress areinvolvedinthecontrolof under condition，over activity ofHPAaxis arisefrom of function．In excitation