职业性皮肤癌常识(Common sense of occupational skin cancer).docVIP

职业性皮肤癌常识(Common sense of occupational skin cancer).doc

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职业性皮肤癌常识(Common sense of occupational skin cancer)

职业性皮肤癌常识(Common sense of occupational skin cancer) An overview of occupational skin cancer Occupational cancer (occupational skin) refers to the skin tumor which is affected by many factors in the course of professional work. Etiology of occupational skin cancer (1) the cause of the disease; 1. chemical carcinogenic polycyclic aromatic hydrocarbons is mainly caused by the occupation of chemical substances, skin tumors including asphalt, tar, soot, carbon black, paraffin and mineral oil, long-term exposure to these substances and their metabolites can induce skin cancer, benzo (3, 4-benzpyrene) is a product of all material containing carbon metabolism in the process of in vivo, by cyclooxygenase, microsomal hydroxylase and a series of functions, namely into epoxide alkylating agent, and nucleic acid binding, interference of genetic information, generate abnormal base pairs or interfere with the complete dissociation and cancerous cause transcription. Long term exposure to arsenic may be carcinogenic arsenic and arsenic compounds caused by the incubation period of 15 years, experiments show that arsenic mainly closed DNA polymerase induced tumor. The chemical is alkylated aromatic amine, to induce skin cancer, azo dyes, acridine yellow, carbamate, tobacco, two methyl nitrosourea, chloroprene, guanidine nitrate, acetyl fluorene and two methyl benzidine etc.. 2. photochemical action, carcinogenic, solar radiation can enhance the carcinogenic effect of polycyclic aromatic hydrocarbons, photochemical substances can also stimulate the carcinogenic effects of ultraviolet (UV), UV carcinogenic spectrum of 240 ~ 320nm, to 290 ~ 300nm carcinogenic strongest. 3. radiation induced cancer on the basis of the original radiation dermatitis, the amount of acceptance is equivalent to 3000cGy, can cause skin cancer, incubation period of about 25~30 years. 4. trauma causes cancer, some occupational injuries occur on the original normal skin, after a considerable period of time in the o

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