DOC-1R蛋白抑制细胞周期S期复制和CDK2序列影响其入核初步地研究.pdfVIP

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DOC-1R蛋白抑制细胞周期S期复制和CDK2序列影响其入核初步地研究.pdf

EffectofDOC一1R onS-Phase Expression Repficafions and ofCDK2DeletionsOUItsNuclear Import ABSTRACT Introduction Cell and withcellular arehot itsassociation regulation cycle carcinogenesis researchareasinmodemcell the and which biology,in disassociationofthe and kinases complex composingcyclinscyclin—dependent themain events the (CDK)aremolecularunderlyingregulatory process. ofthe in CDK2,one membersCDK thecriti— important family,directlyregulates cal incell transitionof cycleprogression GI/S steps including Rwas as andcentrosome identifiedin1999a replication duplication.DOC一1 encodedwas tumor showedtobindCDK2 putativesuppressorgene.The protein vitroand bea inhibitorof in might specific CDK2.TheDOC一1Rproteinmay is one CDK2fromitsnuclear servedas oftheinevitable prevent import,which of forCDK2activation.Inthe

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