肾细胞癌基因组学研究推动靶向治疗发展.pdfVIP

第26卷第8期 生命科学 Vol. 26, No. 8 2014年8月 Chinese Bulletin of Life Sciences Aug., 2014 DOI: 10.13376/j.cbls/2014116 文章编号：1004-0374(2014)08-0814-09 肾细胞癌基因组学研究推动靶向治疗发展 1 1 1 1* 1,2* 张　蒙，杨泽雨 ，谢良富 ，蔡志明 ，吴　松 (1 安徽医科大学深圳市第二人民医院临床医学院，深圳 518000 ；2 中山大学中山医学院，广州 510080) 摘　要 ：肾细胞癌( 简称肾癌) 是肾肿瘤的最主要类型，也是死亡率最高的泌尿系肿瘤之一。对于晚期肾 癌患者来说，治疗方法非常局限。要想找到针对肾癌的特异性治疗方案，需要对肾癌的生物学基础有着深 入的理解。旨在回顾多年来肾癌基因组学的研究进展，从组学方面分析、解释肾癌的生物学基础，找到治 疗靶点，实现针对肾癌患者的特异性治疗，从而推动科学研究向临床实践的转换。 关键词：肾细胞癌；基因组学；测序；靶向治疗 A 中图分类号：R730.59 ；R737.11 文献标志码： Progression of genomic research of renal cell carcinoma propels the development of targeted therapy 1 1 1 1*, WU Song1,2* ZHANG Meng , YANG Ze-Yu , XIE Liang-Fu , CAI Zhi-Ming (1 Clinical Medical College, Shenzhen Second Peoples Hospital, Anhui Medical University, Shenzhen 518000, China; 2 Zhongshan School of Medicine, Sun-Yet-Sen University, Guangzhou 510080, China) Abstract: Renal cell carcinoma (RCC), which belongs to a major class of renal tumors, is one of the most fatal urological cancers. Further, few effective treatments are available to patients at an advanced stage. To find a specific treatment for RCC requires a better understanding of the biology of RCC. We performed an overview of genomics research of RCC to analyze and interprete the biology of RCC and find the therapy targets, thus propelling the conversion of scientific research to clinical practice via delivering specific treatment to RCC patients. Key words: renal cell carcinoma; genomics; sequencing; targeted therapy 肾细胞癌( 简称肾癌) 是起