MR医学影像文献Jiang-2016-Molecular MRI differentiation betwe.pdfVIP

Eur Radiol (2016) 26:64–71 DOI 10.1007/s00330-015-3805-1 MOLECULAR IMAGING Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 Tesla Shanshan Jiang 1,3 Hao Yu 1 Xianlong Wang 1 Shilong Lu 1 Yufa Li 2 Lyujin Feng 1 Yi Zhang 3 Hye-Young Heo3 Dong-Hoon Lee 3 Jinyuan Zhou 3 Zhibo Wen 1 Received: 28 January 2015 /Revised: 18 March 2015 /Accepted: 14 April 2015 /Published online: 30 April 2015 # European Society of Radiology 2015 Abstract 0.001 and 0.05, respectively), while the APTWmin and MTR Objectives To show the ability of using the amide proton were significantly higher (both P 0.01) in PCNSL lesions than transfer-weighted (APTW) MRI signals as imaging bio- in HGG lesions. The APTW values in peritumoral oedema markers to differentiate primary central nervous system lym- were significantly lower for PCNSLs than for HGGs phomas (PCNSLs) from high-grade gliomas (HGGs). (P 0.01). APTWmax-min had the highest area under the ROC Methods Eleven patients with lymphomas and 21 patients curve (0.963) and accuracy (94.1 %) in differentiating PCNSLs with HGGs were examined. Magnetization-transfer (MT) from HGGs. spectra over an offset range of ±6 ppm and the conventional Conclusions The protein-based APTW signal would be a MT ratio (MTR) at 15.6 ppm were acquired. The APTW sig- valuable MRI biomarker by which to identify PCNSLs and nals, total chemical-exchange-saturation-transfer signal (inte- HGGs presurgically. gral between 0 and 5 ppm, CESTtotal), and MTR signal were Key Points obtained and compared between PCNSLs and HGGs. The • PCNSLs overall showed more homogeneo