骨肉瘤凋亡与耐药相关机制的研究进展.pdfVIP

中国骨与关节杂志 2015 年 1 月第 4 卷第 1 期 Chinese Journal of Bone and Joint, January 2015, Vol 4, No.1 . . 45 . 综述 Review . 骨肉瘤凋亡与耐药相关机制的研究进展 陈楷　吕书军　付东　李国东　蔡郑东 DOI: 10.3969/j.issn.2095-252X.2015.01.012　　中图分类号：R738.1 基金项目：国家自然科学基金 ()；教育部博士点基金 ( 20100072120056 ) 作者单位：226600 江苏，南通大学附属海安县人民医院骨科 ( 陈楷、吕书军 )；200072 上海，同济大学附属上海第十 　　　　　人民医院骨科 ( 付东、李国东 )；上海市第一人民医院骨科 ( 蔡郑东 ) Research progress of apoptosis and drug resistance mechanism of osteosarcoma CHEN Kai, L Shu-jun, FU Dong, LI Guo-dong, CAI Zheng-dong. Department of Orthopedics, Haian People’s Hospital, Nantong University, Nantong, Jiangsu, 226600, PRC Abstract Osteosarcoma is one of the most common malignant bone tumors. The cure rate of the traditional 【 】 surgery is low and amputation, lung metastases and death often occur. Currently, the neoadjuvant therapy with the combination of chemotherapy and surgery is an important method in the treatment of osteosarcoma. Abnormal apoptosis and drug resistance of osteosarcoma are major causes of clinical treatment failure. The changes of various genes and protein pathways are noticed with the appearance of abnormal apoptosis and drug resistance of osteosarcoma. The most common apoptosis-related genes include B-cell lymphoma-2 ( Bcl-2 ) family ( Bcl-2, Bax et al. ), Fas / Fas Ligand ( FasL ) family, Caspases, p53 family and so on. The drug resistance genes / proteins cover multidrug resistance-1 ( MDR-1 ), P-glycoprotein ( P-gp ), multi-drug resistance protein ( MRP ), high mobility group box 1 protein ( HMGB1 ) and others. The research on these molecular pathways may help to reveal the mechanism