治疗隐球菌感染新药研究进展novelantifungalagents-药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 17, 52 (6): 859 864 ·859 · 疗隐球菌感染新药研究进展 1 1 1 1 2* 廖国建 , 郑 姣 , 黄宇琪 , 付 琛 , 谢建平 (1. 西南大学药学院现代生物医药研究所, 重庆 400716; 2. 西南大学生命科学学院现代生物医 研究所, 三峡库区生态环境与生物资源省部共建国家重点实验室, 重庆 4007 15) 摘要: 隐球菌感染每年导致超 100 万例患者新增感染及近 60 万例病死报道, 严重威胁公众健康。隐球菌对 目前有限的抗菌 物的耐药性日益严重, 新 研究十分迫切。抗隐球菌 物发挥 效除需具备一般抗真菌药物 的特点外, 需进入宿主细胞以及穿透血脑屏障。筛选具有全新作用机制的小分子化合物和已上市药物 “老 新用”是目前抗隐球菌药物研发的两种主要策略。本文综述了据此获得的抗隐球菌先导化合物或药物的抗菌活 性、作用机制和临床研究进展。 关键词: 新型隐球菌; 隐球菌病; 隐球菌性脑膜炎; 高通量筛选; 老药新用; 舍曲林 中图分类号: R9 16 文献标识码: A 文章编号: 0513-4870 (20 17) 06-0859-06 Novel antifungal agents against cryptococcal infections 1 1 1 1 2* LIAO Guo-jian , ZHENG Jiao , HUANG Yu-qi , FU Chen , XIE Jian-ping (1. Institute of M odern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China; 2. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of E co-Environment and Bio-Resource of the Three Gorges Area, School of life Sciences, Southwest University, Chongqing 400715, China ) Abstract : Cryptococcal meningitis, caused by fungus Cryptococcus neoformans , is responsible for over a million infections and 600 000 deaths annually. Largely due to the limited treatment options and the intrinsic drawbacks coupled with drug resistance to current therapies, it is urgent to discover novel antifungal agents against cryptococcosis. An