星点设计-效应面法优化广金钱草总黄酮固体分散体微孔渗透.PDFVIP

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 21 期 2014 年 11 月 ·3081 · 星点设计-效应面法优化广金钱草总黄酮固体分散体微孔渗透泵控释片处方 赵俊霞，孙彩霞，苏建春，史玉荣，王 浩，尹蓉莉* 成都中医药大学，四川 成都 611130 摘 要：目的 应用星点设计-效应面法优化广金钱草总黄酮（TFDS ）固体分散体微孔渗透泵控释片处方。方法 以促渗剂 用量、致孔剂用量、包衣增重为考察因素，2 、6、12 h TFDS 的累积释放度及线性相关系数为综合评价指标，采用 Design-expert 软件对实验数据进行多元线性模型和二次多项式模型拟合，得出最佳数学模型，绘制效应图，通过数值优化法得到最优处方 并进行验证。结果 二次多项式模型优于多无线性模型，为最终拟合模型；最佳处方的各时间点累积释放度的实际值和预测 值接近，相对偏差绝对值小于 5% 。结论 通过星点设计-效应面法建立的模型预测性良好，可用于对 TFDS 固体分散体微孔 渗透泵控释片处方的优化。 关键词：广金钱草总黄酮；固体分散体；微孔渗透泵控释片；星点设计-效应面法；数值优化法 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2014)21 - 3081 - 06 DOI: 10.7501/j.issn.0253-2670.2014.21.009 Optimization on formulation of microporosity osmotic pump controlled release tablet of solid dispersion for total flavonoids from Desmodium styracifolium by central composite design-response surface methodology ZHAO Jun-xia, SUN Cai-xia, SU Jian-chun, SHI Yu-rong, WANG Hao, YIN Rong-li Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China Abstract: Objective To optimize the formulations of microporosity osmotic pump controlled release tablet of solid dispersion for total flavonoids from Desmodium styracifolium (TFDS) by central composite design-response surface methodology. Methods The independent variables comprised of the amount of lactose, pore-forming agent, and coating weight gain, and the dependent variables involved the cumulative release after 2, 6, and 12 h, and the linear correlation coefficient of cumulative release curve. Design-expert software was used to fit multivariate linear models and quadratic multinomial models for experimental data. Response surface was delineated according to best-fit mathematic models and the optimum formulation was selected by Numerical Optimization. Results The correlation coefficients of quadratic multinomial models were better