纳米载体在肿瘤免疫治疗中的研究进展recentadvancesof-药学学报.pdfVIP

· · 药学学报 Acta Pharmaceutica Sinica 20 17, 52 ( 期): 起页 末页(校样) 1 米载体在肿瘤免疫治疗中的研究进展 李曼，杨玉婷，何勤，张志荣* ( 四川大学华西 学院，四川 成都 61004 1) 摘要: 近20 年来，肿瘤免疫治疗已获得显著进展，众多研究以及临床试验均展现出良好的肿瘤抑制效果。 免疫治疗主要从两方面体现对肿瘤的抑制作用：一是在肿瘤发生期间诱发机体产生有效的抗肿瘤免疫应答，二 是通过免疫记忆实现对肿瘤的长期监控，降低肿瘤复发的可能性。通过纳米载体递送具有治疗作用的免疫调节 剂是目前研究较多的一种免疫治疗策略。研究发现纳米载体具有特殊的理化性质，易于被免疫细胞吞噬，调节 免疫系统反应强度，最终有效诱发机体对于肿瘤的免疫级联反应，实现对肿瘤生长的抑制。本文将对近年来新 型纳米载体介导的抗肿瘤免疫治疗研究进展进行总结。 关键词: 纳米载体; 靶向递送; 免疫治疗; 肿瘤; 疫苗 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 17) Recent advances of nanocarriers in tumor immunotherapy * LI Man, YANG Yu-ting, HE Qin, ZHANG Zhi-rong ( West China School of Pharmacy, Sichuan University, Chengdu 610041, China ) Abstract : In the past 20 years, tumor immunotherapy has made significant progress. which has shown promising tumor inhibition effects by many studies and clinical trails. On one hand, effective antitumor immune response would be induced during the tumor progress; on the other hand, long-term monitoring of the tumor would be achieved through the immune memory, reducing the possibility of tumor recurrence. Plenty of immune treatment strategies have focused on delivering therapeutic immune regulators with nanocarriers. Studied de- monstrated that due to the special physical and chemical properties, nanocarriers could be easily internalized by immune cells, which further regulate the immune responses and effectively induce anti-tumor immune cascade to achieve tumor growth inhibition. Herein, in this paper, we wil