慢性激光刺激对人体衰老的影响-第三军医大学学报.DOC

慢性激光刺激对人体衰老相关指标的影响 唐刚，司良毅（400038 重庆，第三军医大学附属西南医院老年病科) [摘要]慢性激光刺激对人体衰老的影响。在某激光研究所工作人员中研究激光暴露对血浆Kl蛋白、红细胞superoxide dismutase，SOD）及Malondialdehyde，MDA）含量、淋巴细胞端粒长度的影响。激光暴露组和非暴露组之间血浆Kl蛋白、红细胞MDA含量、淋巴细胞端粒长度无明显差异，而红细胞SOD在激光暴露人群于非暴露组，多元回归分析显示SOD主要受年龄、性别、吸烟影响，激光暴露的影响无统计学意义。亚组分析显示吸烟人群在激光暴露时有更低的红细胞SOD。慢性激光刺激对衰老相关指标无直接影响，但吸烟人群中可能导致红细胞SOD降低。 [关键词] [中图法分类号] R；R；R The effect of Chronic Laser on aging of the human body Tang Gang，Si Liangyi （Department of Geriatrics， Southwest Hospital of The Third Military Medical University， Chongqing， 400038， China） [Abstract] Objective To illustrate the effect of Chronic Laser on aging of the human body. Methods: In the present study, we observe the value of K1-protein, SOD and MDA content in red blood cells, and the telomere length in peripheral lymphocytes when the human body expose in the chronic Laser circumstance. Results Compared with control group, the value of K1-protein, SOD and MDA content in red blood cells, and the telomere length in peripheral lymphocytes have no significant difference in chronic laser group. However, the values of SOD in red blood cells decrease significantly in chronic laser group compared with control group. Moreover, according to multiple regression analysis, the value of SOD in red blood cells is determined by the effect of age, sex, and cigarette, and there is no significant difference in chronic laser group when compared with control group. The smoking person with chronic laser exposing has lower value of SOD in red blood cells. Conclusion There is no effect on aging in person with chronic laser stimulation. However, the smoking person may have lower value of SOD in red blood cells. [Keywords] Laser; aging; superoxide dismutase; Malondialdehyde telomere Corresponding author: Si Liangyi, Tel: 86-23 E-mail: doctorsly@126.com 激光急性刺激可对人体造成视觉、神经、生殖、心血管等多系统损害，这一现象已被公认。而慢性刺激引起的机体损害发生较隐匿，目前重视不够。通过研究慢性激光刺激对机体的影响，可对激光作业工作人员的职业防护起到重要作用。本研究拟对某激光研究所工作人员中了解慢性激光刺激对人体衰老相关指标的影响，为慢性激光刺激的防治工作提供依据。 选择某激光研究所参加20年4月体