成纤维细胞生长因子的临床转化及相关新药研究进展.PDF

PROGRESS IN PHARMACEUTICAL SCIENCES 2015,39 10 :781-786 ( ) 781 成纤维细胞生长因子的临床转化及相关新药研究进展 1,2,3 1,2 1,2,3* 惠琦 ，李校堃 ，王晓杰 （1. 温州医科大学药学院，浙江 温州   325035；2. 浙江省生物制药工程重点实验室，浙江 温州   325035；3. 浙江格鲁斯特生物科技有限公 司，浙江 温州 325035） [ 摘要 ] 成纤维细胞生长因子（FGF）调节人体发育的过程，以旁分泌或内分泌的方式调控血管形成、损伤修复、胚胎发育和代谢调控等一 系列重要生理病理过程。FGF用于烧伤创面及慢性溃疡创面治疗已经有新药上市应用。最近发现的以内分泌方式调控胆汁酸、葡萄糖和磷 酸盐平衡的FGF19亚家族将拓展FGF家族的新功能。综述FGF在创伤修复、糖尿病、低磷血症等疾病治疗中的应用，以及FGF受体抑制 剂作为抗肿瘤药物的研究进展，探讨FGF在中国的基础与应用研究进展。 [ 关键词 ] 成纤维细胞生长因子；创伤修复；代谢调控；成纤维细胞生长因子受体抑制剂 [ 中图分类号 ]  Q71                             [ 文献标志码 ] A                    [ 文章编号 ] 1001-5094（2015）10-0781-06 Progress in Clinical Transformation of Fibroblast Growth Factors and Related New Drug Development HUI Qi1,2,3, LI Xiaokun1,2, WANG Xiaojie1,2,3 (1.Pharmacy School of Wenzhou Medical University Wenzhou 325035,Cnina 2.Key Laboratory of Biotechnology Pharmaceutical Engineering of , ; Zhejiang Province Wenzhou 325035,Cnina 3.Zhejiang Groster Biological Technology Co., Ltd., Wenzhou 325035,Cnina) , ; [Abstract] The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes. FGFs signal in a paracrine or endocrine fashion to mediate a myriad of biological and pathophysiological processes, ranging from angiogenesis, wound healing, embryonic development to metabolism regulation. FGF drugs for burn and ulcer wounds have already reached the market.The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose and phosphate further extended the activity profile of this family.