虫草对肺部疾病治疗的研究进展areviewof-现代生物医学进展.pdfVIP

·6786 · 现代生物医学进展 Progress in Modern Biomedicine Vol.14 NO.34 DEC.2014 doi: 10.13241/j .cnki.pmb.2014.34.048 虫草对肺部疾病治疗的研究进展 1 1,2 2 1 1 张颖茁 杨晓彤 杨庆尧 冯慧琴 杨明俊 (1 200234 2 200234) 上海师范大学微生物与免疫学研究所 上海 ；上海杨杨百草研究所 上海 ： ，它们均以肺部或呼吸道的慢性炎症为特征，当前的治疗方 摘要 肺纤维化、慢性阻塞性肺病和哮喘是人类主要的呼吸系统疾病 法尚不理想并伴随着很 的副作用，人们迫切需要一种更安全的替代疗法。冬虫夏草是我国传统的名贵药用真菌，被广泛用来治 疗 种肺部疾病。近年来，冬虫夏草对肺部疾病治疗作用的研究取 了较大进展，本文综述了冬虫夏草、其无性型中国被毛孢 (Hirsutella sinensis 或Ophicordyceps sinensis)和其他相关虫草及其提取物对肺纤维化、慢性阻塞性肺病、哮喘等肺部疾病治疗作用 的研究进展，并介绍了其作用机制的研究成果。 ： ；哮喘 关键词 冬虫夏草；慢性阻塞性肺病；肺纤维化 285.5 R563 Q939.9 A 1673-6273 20 14 34-6786-03 图分类号： ； ； 文献标识码： 文章编号： （ ） A Review of Cordyceps in Treatment of Lung Diseases Lung fibrosis, COPD and Asthma are the principal respiratory diseases. They are all characterized by chronic inflammation of the Lung or airway. The current therapies are inadequate and have numerous adverse effects. There is an acute need of potential alternative therapies. Cordyceps sinensis is one of the most valuable Chinese herbal medicines. It is widely used for treating various lung disease. In recent few years, understanding of Cordyceps sinensis in treating lung diseases has made much progress. This paper summerized the advances of Cordyceps sinensis and its anamorph Hirsutella sinensis, and other correlated species and their extracts for lung fibrosis, COPD and Asthma treatment, and reviewed the mechanisms. Cordyceps; Lung fibrosis; COPD; Asthma ; ; 冬虫夏草(Cordyceps sinensis)生长在高海拔地区，是冬虫 增生、大量细胞外基质过度沉积侵占肺泡结构间隙，肺泡结构 夏草菌(Ophiocord