炎症反应过程中药物转运体调控的研究进展areviewon-药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 11, 46 (7) : 773779 ·773 · 炎症反应过程中药物转运体调控的研究进展 * 行, 毕惠嫦, 黄 民 ( 中山大学药学院, 物代谢与药动学实验室, 广东 广州 510006) 摘要: 炎症状态下机体对药物的处置过程会发生显著改变, 众多药物代谢酶及转运体的表达和功能发生下 调。研究表明机体在该状态下会释放一系列炎症细胞因子对 物代谢酶的表达和功能产生调控, 而近年来的研 究表明在炎症状态下药物转运体也受到这些细胞因子的调控, 且部分转运体的调控呈现明显的种属差异性。进 一步的机制研究表明, 一些转录因子在调控的信号通路中发挥了重要的作用。本文对炎症状态下药物转运体的 调控研究进展进行综述。 关键词: 药物转运体; 炎症; 细胞因子; 转录因子; 种属差异 中图分类号: R969 文献标识码:A 文章编号: 05 13-4870 (20 11) 07-0773-07 A review on regulation of drug transporters during inflammation * ZENG Hang, BI Hui-chang, HUANG Min (Laboratory of Drug M etabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China) Abstract: Drug metabolism will change significantly during inflammation, including the reduction of expression and activity of many drug metabolizing enzymes and transporters. Body would release a series of inflammatory cytokines which can regulate drug metabolizing enzymes. Recent studies have revealed that drug transporters are also regulated by the cytokines with obvious species difference. Mechanism studies show that several transcription factors play important roles during the signal pathways of regulation . This review focuses on the progress in the regulation of drug transporters during inflammation. Key words: drug transporter; inflammation ; cytokine; transcription factor