(神经病学）脑炎7年制英语.pptVIP

History 1957 Gajdusek and Zigas---- Kuru 1959 Klatzo same pathology between kuru and CJD 1966 Gajdusek Kuru orangutan 1968 Gibbs CJD orangutan 1997 Prussiner Prion Prion protein disease (朊蛋白疾病) PrPc is not nucleic acid in cell, and PrPsc can have transmission of the disease. Due to the PrPsc cause characteristic neuropathology changes that are sporadic forms of spongiform degeneration, It was classified subacute spongiform encephalopathy (SSE). PrPsc 是通过PrPc a-螺旋重折叠成β折叠而变成异构体。不被蛋白酶k消化。 PrPsc may resist a series of routine antisepsis. At present, PrP is encoded b