芍药甘草口服液提取、精制工艺线路设计.docVIP

设计任务书 一、设计题目 芍甘复方提取、精制工艺设计1提取工艺·······················································5 2.2精制工艺·······················································5 3、实验内容··························································6 3.1、实验目的······················································6 3.2仪器与试剂·····················································7 3.3实验内容·······················································7 3.4检测···························································7 3.5实验数据·······················································8 3.6实验讨论······················································10 4、参数确定·························································10 4.1提取工艺······················································10 4.2精制工艺······················································10 4.3工艺线路设计··················································10 4.4工艺流程图····················································11 5、工艺线路·························································11 5.1提取与精制工艺················································11 5.2成型工艺······················································12 5.3生产数据表····················································12 6、 结束语··························································13 7、参考文献·························································14 1、概述 1.1经典处方 芍药12g 甘草12g 1.2用法用量 上二味，用水600毫升，煮取300毫升，去滓，分温再服。 1.3功能主治 本方主治津液受损，阴血不足，筋脉失濡所致诸证。方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效。 1.4中药效物质成分类型、性质及药理作用 芍药甘草汤由芍药甘草两味药组成，主要成分为芍药苷、甘草酸以及甘草苷。 芍药 芍药苷为芍药中的主要成分，在酸性环境下芍药甙稳定（pH2～6），在碱性环境下不稳定。具有扩张血管、镇痛镇静、抗炎抗溃疡、解热解痉、利尿的作用。 甘草 甘草酸是甘草中最主要的活性成分。甘草酸及其系列产品，对肉瘤、癌细胞生长有抑制作用，对艾滋病的抑制率更高达90%，有较强的增加人体免疫功能作用，而且也是很好的食品添加剂和香料基料。作为药物，具有抗炎、抗变态反应；作为甜味剂，广泛用于各类食品 。 甘草苷甜度为蔗糖的100~500倍。甜味缓慢、存留时间长。作为甜味改良剂或增强剂时，一般与别的甜味剂混合使用 。具有抗抑郁作用、神经保护作用、对肝脏毒性保护作用、对心脏系统的作用以及对治疗咽炎，治疗急慢性咳嗽和痰多等症状都具有药理作用【1】。 2、工艺选择 2.1提取工艺 水提法 制成口服液，采用水提法，可避免用醇提取后对人体产生副作用或药理作用，同时可降低生产成本。 2.2精制工艺 2. 2.1常用技术 醇沉工艺 原理是中药有效成分(如生物碱盐类、苷类等)既溶于水又溶于乙醇，用适当浓度的乙醇经一次或多次沉降可以有效地除去