质子泵抑制剂与肿瘤耐药研究.PDFVIP

19 1 Vol. 19, No. 1 2007 2 Chinese Bulletin of Life Sciences Feb., 2007 1004-0374(2007)01-0009-05 · · 1 212013 2 200032 pH pH Q51; R969.4; R978.7A Studies of proton pump inhibitors and tumor resistance to antitumor drugs 1 2 1,2 JIN Jie , QIN Wenxin *, YANG Shengli (1 School of Life Sciences, Jiangsu University, Zhenjiang 212013, China; 2 National Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University Medical School, Shanghai 200032, China) Abstract: Resistance to antitumor agents is a major cause of treatment failure in patients with cancer. Some mechanisms of tumor resistance to cytotoxic drugs may involve increased acidification of extracellular compartments. An option to revert multi-drug resistance is the use of agents that disrupt the pH gradient between the extracellular environment and the cell cytoplasm in tumours. Proton pump inhibitors (PPIs), a class of V-H+ -ATPase inhibitors and currently used in the anti-acid treatment of peptic disease, could inhibit the acidification of the tumor microenvironment and increase the sensitivity of tumor cells to cytotoxic agents by inhibiting the function of pumps generating the pH gradient. Key words: proton pump inhibitors; tumor resistance; acidity (1) multidrug resistance, MDR) (2) (3) (topoisomerase , TOPO MDR )TOPO 2006-03-20 2006-05-15 973 (2002CB513100)