白念珠菌铁稳态调控网络研究进展.pdfVIP

微生物学通报 MAR 20, 2012, 39(3): 386−393 Microbiology China © 2012 by Institute of Microbiology, CAS tongbao@ 专论与综述 白念珠菌铁稳态调控网络研究进展 徐宁 程欣欣 喻其林 邢来君 李明春* (南开大学 微生物学系 分子微生物学与技术教育部重点实验室 天津 300071) 摘 要: 铁是绝大多数生物生长和代谢过程中必需的营养元素。尽管自然界中铁元素含 量非常丰富, 但是其生物可利用性却很低。作为一种人体常见的条件致病真菌, 白念珠菌 在漫长的进化过程中形成了复杂的铁稳态调控网络, 能够应答环境中铁浓度的变化, 增 强菌株对环境的适应力。结合课题组研究工作, 简要综述近几年关于铁代谢表达调控途径 的研究进展, 主要关注白念珠菌在环境铁匮乏条件下铁获得和调控策略, 揭示白念珠菌 体内铁离子摄取、转运、储存和利用机制。 关键词: 铁, 铁调控, 铁获得, 铁应答基因, 白念珠菌 Research advances of iron homeostasis regulatory networks in Candida albicans * XU Ning CHENG Xin-Xin YU Qi-Lin XING Lai-Jun LI Ming-Chun (Key Laboratory of Molecular Microbiology and Technology , Ministry of Education, Department of Microbiology , Nankai University, Tianjin 300071, China) Abstract: Iron is an essential element that is required for the growth and normal metabolism in most organisms. However, despite its much abundance in the Earth’s crust, the bioavailable form of iron is very poor. To obtain iron in the environment, Candida albicans, as a common opportun- istic human fugal pathogen, has evolved the iron regulatory networks to respond to the fluctuations in iron availability, which is associated with the adaptation to the hostile environment. As well as our study, this paper reviews the research advances of iron regulatory networks in recent years, focusing on the iron acquisition and r