人肠道菌对天然产物代谢及转化的研究进展-微生物学报.pdf

微生物学通报 Sep. 20, 2014, 41(9): 1872−1881 Microbiology China © 2014 by Institute of Microbiology, CAS tongbao@ DOI: 10.13344/j.microbiol.china.130795 专论与综述 人肠道菌对天然产物代谢及转化的研究进展 赵磊 陈剑 任冰如 李维林* (江苏省中国科学院植物研究所 江苏省抗糖尿病药物筛选服务中心 江苏 南京 210014) 摘 要：天然产物的人肠道菌代谢及转化研究已引起各国学者的重视，并作为热点课题进行了 大量研究工作。本文对近二十年来各国学者关于黄酮类、萜类、苯丙素类、生物碱类、甾体类 及其他天然产物的人肠道菌代谢及转化研究工作进行了综述，总结了各类天然产物在人肠道菌 作用下的代谢路径及转化规律，以期为该领域的进一步深入研究提供参考。 关键词：人肠道菌，天然产物，代谢，转化 Advances in study on metabolism and biotransformation of natural products by human intestinal bacteria * ZHAO Lei CHEN Jian REN Bing-Ru LI Wei-Lin (Jiangsu Provincial Service Center for Antidiabetic Drugs Screening , Institute of Botany, Jiangsu Province and the Chinese Academy of Sciences , Nanjing, Jiangsu 210014, China) Abstract: The study on metabolism and biotransformation of natural products by human intestinal bacteria is receiving more and more attention. To gain insight and to trigger additional research in this field, we provide in this an overview of selected natural products bio-transformed or metabolized by human intestinal bacteria through the reported literatures in recent 20 years. The mechanism as well as pathway of metabolism or bio-transformation by human intestinal bacteria was discussed, according to the categories of natural products such as flavonoids, terpenoids, phenylpropanoids, alkaloids, steroids and the others. We also address the needs in further studies on metabolism and conversion act