GP方案联合伽玛刀治疗局部晚期非小细胞肺癌临床分析.pdfVIP

· 2236· GP方案联合伽玛刀治疗局部晚期非小 GP方案联合伽玛刀治疗局部晚期tPd,细胞肺癌临床分析 张 姣，沙晓锋，宗 毅，曹海英，韦淑贞，张 闯 Clinicalanalysisofgemcitabinepluscisplatincombinedwithbodyy—knifeconcurrent Chem0radi0fherapy in patientswith locally advanced non—smallcelllung cancer (NSCLC) ZhangJiao，ShaXiaofeng，ZongYi，CaoHaiying，WeiShuzhen，ZhangChuang The82ndHospitalofPLA(ArmyTumorRadiationTherapyCenter)，JiangsuHuai?m223001，China． 【Abstract】 Objective：Toevaluatetheclinicaleffectandtoxicotyofgemcitabine(GEM)pluscisplatin(DDP)con— binedwithbody 一knifeconcurrentchemoradiotherapyforlocallyadvancedNSCLC．Methods：A1l76patientswere treatedwithGEMplusDDPcombinedwithbody 一knifeconcurrentchemoradiotherapy．”GP”projectwasgivenat least2cycles．Radiationwasdeliveredwithacumulatedmarginaldoseranged40—49Gy．Clinicaleffectswereevalua— tedthreemonthsafterthe 一knifetreatment．Results：Thetotal efficacyrateWaS86．84％ ．Acuteradiationinduced lunginjurywas23．68％(I—II)，cuteradiationinducedesophagusinjurywas19．74％(I—II)，bone—ma~ow toxicity13．16％(HI)，bone—marrowtoxicity1．32％ (IV)．Thesurvivalratesat1，2yearwere67．11％ and 42．11％ ．Thetoxicityoflung．esophaug sandbloodin76patientswerewelltoleratedandallpatientscompletedtheir treatmentsuccessfully．Conclusion：GEM plusDDPcombinedwithbody 一knifeconcurrentchemoradiotherapyofr thelocallyadvancedNSCLCshowedbettereffectandtolerabletoxicityinmostpatients．Nodeathsrelatedwithtreat— ment． K【eywords】non—smallcelllungcancer；body 一knife；gemcitabine；cisplatin；concurrentehemoradiotherapy Modem Oncology2013，21(10)：2236—2238 【摘要】 目的：评价 GP(吉西他滨 +顺铂)联合体部伽玛刀治疗局部晚期非小细胞肺癌的临床疗效及毒副反 应。方法：76例局部晚期tN,细胞肺癌均予以GP方案化疗联合体部伽玛刀，每个患者至少完成 2周期化 疗 ，行体部伽玛刀放疗总量 DT40—49Gy。伽玛刀治疗结束后3月评价临床疗效。结果：近期总有效率为 86．84％(66／76)。1年生存率、2年生存率分别为67．11％(51／76)、42．11％(32／76)。急性放射性食管损伤 (I一Ⅱ度)发生率为 19．74％(15／76)，急性放射性肺损伤 (I一