结节性甲状腺肿论文：结节性甲状腺肿疏肝散结方优甲乐最大结节直径.docVIP

结节性甲状腺肿论文：结节性甲状腺肿 疏肝散结方 优甲乐 最大结节直径 【中文摘要】应用疏肝散结方治疗结节性甲状腺肿(简称结甲)肝气郁结型,并与西药优甲乐对照,观察疏肝散结方对结甲肝气郁结型的疗效。方法：用平行对照法将70例符合纳入标准的结甲患者分为两组：中药组(n=35,口服疏肝散结方)和对照组(n=35,口服优甲乐片),3个月为一个疗程。观察两组治疗前后的相关指标(包括症状体征、B超测定的甲状腺体积及结节的最大直径、甲状腺功能、抗甲状腺自身抗体等),并作比较分析。结果：疗程结束时,可供统计的有效病例分别为：疏肝散结方组33例,优甲乐组31例。(1)两组疾病疗效比较：中药组：总有效率为72.7%；对照组：总有效率为32.3%；两组比较均有显著性差异(P0.05)；对照组的TSH治疗后较治疗前明显降低(P30%)。对照组3例TGAb阳性,治疗后3例均无明显改善(30%,1例改善不足30%；对照组1例TPOAb阳性,治疗后改善不足30%。结论：(1)疏肝散结方中药组的疾病疗效高于优甲乐对照组,且患者的证候改善程度高于优甲乐组,结节的缩小程度大于优甲乐组,说明中药疏肝散结方治疗结甲优于西药优甲乐。(2)疏肝散结方的疗效与最大结节直径密切相关,对直径2.5cm的结节疗效好,对≥2.5cm的疗效差。(3)疏肝散结方对于甲状腺激素分泌无明显影响,毒副作用小,安全性高。 【英文摘要】:To estimate the therapeutic effect of “ShuGanSanJie” prescription on nodular goiter (NG) patients whose syndrome type are liver qi depression, and make comparison with patients treated with euthyrox.Methods:Seventy NG patients were divided parallel comparatively into two groups:the traditional Chinese medicine group (n=35, to be treated with “ShuGanSanJie” prescription) and the compared group ((n=35, to be treated with euthyrox), three months for a treatment course. Observe and analyze comparatively the related indicators (including related symptoms and signs, thyroid nodule volume and the maximum diameter measured by ultra-sound test, the thyroid function, anti-thyroid autoantibody).Results:After the treatment, all cases statistically available are 64 patients, in which 33 cases belongs to the traditional Chinese medicine group, while 31 cases belongs to the compared group.(1) Comparison on disease therapeutic effect between the two groups:the traditional Chinese medicine group:The total effective rate was 72.7%; the compared group:The total effective rate was 32.3%; Two groups were different significantly (P0.05). The TSH of the compared group was significantly lower after the treatment (P30%). All the 3 TGAb positive patients in the compared group showed no significant improvement (30%), and 1 of them improved less than 30%.1 TPOAb positive patient in the compared group showed no