儿童幽门螺杆菌感染情况研究.doc

儿童幽门螺杆菌感染情况研究 　　【中图分类号】R573 【文献标识码】A 【文章编号】1672-3783（2013）11-0636-01 【摘要】 目的 了解本地区儿童幽门螺杆菌（Hp）感染情况，为儿童消化系统疾病的预防治疗奠定基础。方法 对我院2012年7月至2013年6月儿童全血样本共2935例，用免疫胶体金法检测幽门螺杆菌IgG抗体及现症感染蛋白抗体，将结果在男、女性别组，各年龄组分别进行统计分析。结果 本地区儿童幽门螺杆菌总的阳性感染率为21.1%；男女性别感染率分别为22.3%和20.0%，差异无统计学意义（P0.05）。各年龄组感染率随年龄增长递增。结论 幽门螺杆菌抗体阳性者为感染人群或既往感染者，讨论其感染原因以及与性别、年龄的相关性，以及与胃炎等相关疾病的联系，建议重视儿童幽门螺杆菌的高感染率和其致病性。 【关键词】 儿童；幽门螺杆菌；既往感染；现症感染 Analysis of Helicobacter pylori infection in children Fen Li，Dan Huang （Department of Laboratory，Mianyang Central Hospital，Sichuan 621000） 【Abstract】 objective To investigate the infection of Helicobacter pylori in children of the region，and to prevent or treat the digestive diseases in children.Methods A total of 2935 blood samples of children，collected from July 2012 to June 2013 in Mianyang Central Hospital，Helicobacter pylori IgG antibodies and current infection antibodies were detected by Immune colloidal gold.The results was compared among the sex and the groups of age.Results Helicobacter pylori positive rate in children was 21.1%，and the positive rates in boys and girls were 22.3%and 20.0%.There was no significant difference in the positive rate between the boys and girls（P0.05）.Prevalence increased with age in each age group increments.Conclusion The children that Helicobacter pylori antibodies positive were infected by Helicobacter pylori.Discuss the cause of infection and the relationship with sex and age，as well as gastritis and other diseases associated with the contact，We should pay great attention to the high prevalence of Helicobacter pylori and its pathogenicity in children. 【Key words】 children；Helicobacter pylori；past infection；current infection 幽门螺杆菌（Helicobacter pylori，Hp）是1983年Marshall和Warren首次从慢性活动性胃炎、消化性溃疡患者的胃黏膜活检标本中分离成功的，随后他们证明该细菌感染胃部会导致胃炎、胃溃疡和十二指肠溃疡等。Hp已被确认与消化性溃疡、慢性胃炎、胃黏膜相关淋巴样组织淋巴瘤和胃癌等消化系统疾病密切相关。1994年世界卫生组织（WHO）国际癌症研究机构（IARC）已将Hp列为Ⅰ类致癌源。为了解川西北地区儿童感染幽门螺杆菌状况，对我院2012年7月至2013年6月健康体检儿童Hp检测结果进行流行病学统计分析，现将结果报告如下。 1 材料与方法 1.1 标本来源与采集 2