α-硫辛酸、甲钴胺联合治疗糖尿病周围神经病变的临床疗效评价.docVIP

α-硫辛酸、甲钴胺联合治疗糖尿病周围神经病变的临床疗效评价 詹新良 深圳市宝安区松岗人民医院 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 研究α-硫辛酸、甲钴胺联合治疗糖尿病周围神经病变的临床效果。方法 100例糖尿病周围神经病变患者作为研究对象, 采取计算机随机数字分组法将患者分为对照组及观察组, 每组50例。对照组采用甲钴胺治疗, 观察组采用甲钴胺联合α-硫辛酸治疗。比较两组患者的临床疗效、不良反应发生率以及震动感觉阈值。结果 观察组总有效率为96%, 明显高于对照组的80%, 差异具有统计学意义 (P0.05) 。观察组不良反应发生率为6%, 与对照组的4%比较, 差异无统计学意义 (P0.05) 。观察组左右两侧震动感觉阈值均低于对照组, 差异具有统计学意义 (P0.05) 。结论 在糖尿病周围神经病变中, 采用α-硫辛酸与甲钴胺联合治疗的临床疗效显著, 安全性也相对可靠。 关键词： 糖尿病周围神经病变; 甲钴胺; α-硫辛酸; 收稿日期：2017-08-04 Evaluation on clinical efficacy of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy ZHAN Xin-liang Shenzhen City Baoan District Songgang Peoples Hospital; Abstract： Objective To study the clinical effect of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods A total of 100 patients with diabetic peripheral neuropathy as study subjects were divided by computer random number grouping method into control group and observation group, with 50 cases in each group. The control group was treated with mecobalamin, and the observation group was treated with mecobalamin and α-lipoic acid. Comparison were made on clinical efficacy, incidence of adverse reactions and vibration perception threshold between two groups. Results The observation group had obviously higher total effective rate as 96% than 80% in the control group, and the difference was statistically significant (P0.05) . The observation group had incidence of adverse reactions as 6%, and it had no statistically significant difference comparing with 4% in control group (P0.05) . The observation group had lower left and right vibration perception threshold than the control group, and the difference was statistically significant (P0.05) . Conclusion Combination of α-lipoic acid and mecobalamin shows significant clinical efficacy in diabetic peripheral neuropathy, and it is safe and relatively reliable. Keyword： Diabetic periph