鸡蛋免疫治疗进展.doc

Hyperimmune Eggs ? Hyperimmune or immune eggs are laid by hens that typically have been stimulated multiple times with whole or parts of inactivated microorganisms, or purified antigens. The preparation may contain different species or strains of organisms (polyvalent “hyperimmune” egg) (1), or pathogens of a single group (monovalent “hyperimmune” egg (2). ? Stimulating the hens results in eggs that contain immunoglobulins (antibodies) of many classes, with the dominant class being the unique avian IgY* class (3). Upon ingestion, much of the immunoglobulin is apparently still able to bind antigen despite exposure to digestive enzymes (4). ? Along with the production of antibodies, stimulation of the hens results in generation of small molecules that appear to have pro-, and anti-inflammatory properties (5).? By up- or down-regulating immunological responses, especially those of an autoimmune or inflammatory nature, these factors appear to help the body initiate defenses against pathogens, mutating cells, and help maintain immune homeostasis. ? [During inflammatory responses, different categories of effector immune cells communicate with one another via biological mediators (e.g., cytokines, ecosanoids) to modulate inflammatory processes (6). Inflammatory processes appear to the hallmarks of many acute and chronic conditions (7) including atherosclerosis (8-11), diabetes (8-10), and obesity (9-13).] ? Polyvalent hyperimmune egg appears to have immunoregulatory properties that modulate autoimmune (14,15),? joint (14,15), cardiovascular (16), and gastrointestinal (17,18) function.? Hyperimmune egg appears to “balance” immunologic responses, rather than “boost” or unnecessarily “enhance” these processes.? ? Additionally, major quality of life changes are experienced by individuals with HIV/AIDS (19, unpublished).? Of note also are the dramatic differences seen in athletic performance, endurance, recovery and strength in individuals consuming hyperimmune egg (20, 21).