肿瘤信息学.pdf

肿瘤信息学 徐鹰 佐治亚大学生化系、 吉林大学计算机学院 2 Lecture II Tissue structures, chronic inflammation and cancer micro-environment 3 Homework •Reading •Cancer is a functional repair tissue, Med Hypotheses. 2006 •Chronic inflammation and cancer, Cancer Network, 2002. •Inflammation and Cancer, Nature, 2002. 4 •Study of a disease from cell to tissue level But it should be noted that cancer is also a tissue level problem. It is the tissue level microenvironment, tissue-level instructions and constraints that define what a cell can or cannot do Cancer cells have Fenton reactions, oxidative stress, off-balance pH, hypoxia, molecular damages 5 Chronic Inflammation and Cancer •Chronic inflammation has long been known to be associated with cancer development, which can be traced back to as early as over 150 years ago (Rudolf Virchow) •Recent studies suggest that inflammation is a critical component of any cancer •However the causal relationships between the two are currently unknown 6 Coussens and Zena, Nature (2002) Tissue Structure 7 8