一氧化氮合酶与脓毒症的进展.pdfVIP

1366 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.7 APR.2011 ·专论与综述· 一氧化氮合酶与脓毒症的研究进展* 史衍辉 夏 璐 闫 兵 张 军 张永久△ ( 830000 兰州军区乌鲁木齐总医院 新疆乌鲁木齐 ） 摘要：脓毒症在外科临床工作中较常见，治疗相当困难；本文主要概述了一氧化氮合酶的基因定位、结构特点以及一氧化氮合酶 与脓毒症的关系，进一步说明由一氧化氮合酶介导的一氧化氮生成与脓毒症关系密切，而选择性一氧化氮合酶抑制剂在脓毒症 各阶段恰当的应用可能是有效治疗脓毒症、降低病死率的一个重要途径，也将成为今后研究的热点。 NO synthase NOS 关键词：一氧化氮合成酶（ ）；脓毒症 R631.2 A 1673-6273 2011 07-1366-03 中图分类号： 文献标识码： 文章编号： （ ） The research progress of NOS and Sepsis* SHI Yan -hui, XIA Lu, YAN Bing, ZHANG Jun, ZHANG Yong -j iu△ (Urumuqi General Hosp ital of Lanzhou Military Region of PLA Urumuqi 830000, China) ABSTRACT: Sepsis is commonly seen in clinical surgery, it is very difficult to be cured. The genic location and the structure features of NOS (nitric oxide synthase) and the relationship between NOS and sepsis were reviewed in this article, we found that sepsis was related closely with the producing of nitric oxide induced by selective nitric oxide synthase inhibitors, and appropriate using of selective nitric oxide synthase inhibitors in each phase of sepsis might be an important way to cure sepsis and cut down its mortality, which could be a focus in future study. Key words: NOS; sepsis Chinese Library Classification: R631.2 Document code: A Article ID: 1673-6273(2011)07-1366-03 sepsis NOS2(inducible NOS, iNOS) 脓毒症（ ）是全身炎症反应的表现。当脓毒症合并有 合酶 最早在粒细胞中发现，它在细 器官灌注不足的表现，如乳酸中毒、少尿、急性神志改变等，则 胞受到刺激而被激活后才发挥功效，并且所生成的一氧化氮数 sepsis syndrome nNOS iNOS eNO