hs-crp与cta冠状动脉造影不同类型斑块及狭窄程度之间的相关性研究.docVIP

精品论文 参考文献 hs-CRP与CTA冠状动脉造影不同类型斑块及狭窄程度之间的相关性研究 代小兵 何川东 钟唐力 何 瑜 周 莹 孙 凤 刘启榆通讯作者 　　绵阳市中心医院放射科 四川绵阳 621000 　　【摘 要】目的：探讨hs-CRP与冠状动脉CTA不同类型斑块及狭窄程度之间的相关性。方法：回顾性分析352名无症状的临床诊断冠心病患者的冠状动脉CTA资料。分别采用单因素方差分析和多因素logistic回归分析不同斑块类型间hs-CRP浓度差异及hs-CRP与冠状动脉斑块及血管狭窄程度之间的关系。结果：非钙化型组(NCAP)和混合型斑块组(MCAP)hs-CRP浓度与钙化斑块组(CAP)hs-CRP之间差异有统计学意义(P lt; 0.05)，而NCAP组和MCAP组之间hs-CRP浓度差异无统计学意义(P = 0.384)；纳入传统心血管疾病危险因素后行多因素logistic回归分析显示hs-CRP浓度是NCAP形成及冠状动脉显著狭窄的独立预测因素（odds ratio = 1.70, P = 0.025; odds ratio = 1.76, P = 0.020)。结论：hs-CRP浓度与无症状冠心病患者CTA冠状动脉造影中NCAP形成及血管显著狭窄相关，因此hs-CRP浓度对冠心病患者的临床诊断及危险程度评估有重要意义。 　　【关键词】超敏C反应蛋白；冠状动脉疾病；CT血管成像；危险因素 　　【中图分类号】R541 【文献标识码】A 【文章编号】1674-8999（2015）9-0586-02 　　【Abstract】Objective:To determine whether hs-CRP is related to the presence of subclinical coronary plaque and stenosis. Methods:352 subjects who underwent CTA for the assessment of coronary artery disease (CAD) were studied. All the subjects enrolled had no clinical cardiovascular disease symptoms. The presence of plaque type (calcified, mixed calcified, or noncalcified), stenosis degree, and hs-CRP levels were evaluated. Analysis of variance (ANOVA) was used to compare the hs-CRP levels of three groups (calcified, mixed calcified, or noncalcified plaque). Multivariate logistic regression analysis was used to evaluate the association of C-reactive protein with coronary plaque subtype and stenosis. Results:The levels of hs-CRP in the noncalcified and mixed plaque group were significantly higher than those in calcified plaque group (P lt; 0.05), but there was no statistical difference between the noncalcified and mixed plaque group (P = 0.384). Multivariate adjustment for traditional cardiovascular risk factors through logistic regression analysis showed that hs-CRP level was an independent predictor for the presence of noncalcified plaque ( odds ratio = 1.70, P = 0.025) and significant (50% and higher) coronary stenosis (odds ratio = 1.76, P = 0.020). Conclusion:Our study shows hs-CRP is indepe