奥美拉唑联合凝血酶治疗重型颅脑外伤并胃出血的疗效评价.docVIP

精品论文 参考文献 奥美拉唑联合凝血酶治疗重型颅脑外伤并胃出血的疗效评价 陈嘉铭 李文东 　　【摘 要】 目的 探讨奥美拉唑联合凝血酶治疗重型颅脑外伤合并胃出血的疗效。 方法 将82例重型颅脑外伤合并胃出血患者随机分为2组。对照组给予静脉滴注奥美拉唑，同时胃管内注入氢氧化铝凝胶。治疗组在对照组治疗的基础上胃管内注入凝血酶1000U。记录每日胃液隐血试验结果，止血时间和用药前后血常规，肝、肾功能。结果 治疗组和对照组止血的总有效率分别为93.0%和69.2%，两组的差异有统计学意义（plt;0.05）；治疗组和对照组的平均止血时间分别为39.2plusmn;8.4h和70.2plusmn;6.3h，两组的差异有统计学意义（plt;0.05）。用药后两组血常规，肝、肾功能均未出现明显异常。结论 奥美拉唑与凝血酶联合治疗重型颅脑外伤合并胃出血疗效可靠，且不良反应少，值得临床推广使用。 　　【关键词】 重型颅脑外伤； 胃出血； 奥美拉唑； 凝血酶 　　 　　【Abstract】 Objective To study the clinical effect of omeprazole combined with thrombin in the treatment of gastrorrhagia after severe craniocerebral trauma.Materials and methods 82 patients with gastrorrhagia after severe craniocerebral trauma were randomly divided into two groups. The control group was treated with omeprazole 60mg, intravenous drip，once per 12 hours，and aluminium hydroxide gel 5ml was injected into nasogastric tube，once per 8 hours，5 days for a treatment cycle.The treatment group was combined with thrombin on the basis of control group. Results of gastric juice occult blood test, average hemostasis time were recorded. Routine blood, liver and kidney function before and after treatment were observed.Results The total effective rate of treatment group was 93.0%, significantly higher than 69.2% of control group (P lt;0.05). The average hemostasis time of treatment group was significantly shorter than those of control group (P lt;0.05); During treatment, the incidence of adverse reactions of observation group was 2.86%, significantly lower than 22.86% of control group (P lt;0.05). Routine blood, liver and kidney function before and after treatment were in a normal levels in two groups.Conclusion Omeprazole combined with thrombin has an accurate clinical effect for the treatment of gastrorrhagia after severe craniocerebral trauma and has few adverse reactions，so it is worthy of clinical application. 　　【Key words】 severe craniocerebral trauma；gastrorrhagia；omeprazole；thrombin 　　重型颅脑外伤具有较高的发生率、病死率和致残率[1] ，严重威胁着患者的生