2甲氧基雌二醇静脉注射乳剂药剂学性质研讨.pdfVIP

p单氧基雌二醇静脉注射乳剂翁剂学性质研究 张丽娜路红玉张正全 (滞州太学翡学院，郑州450001) 潦薹：料豹对炉l=}jl溉蕊雌三醇(2-ME)静躲注射数躺的嫂化性蕊、稳宠性及钵外释蓊谶往考察，评馀麓藤娥* 方法；纳米糕壤使测巍剩核镪、辫嘲瀚豢斌验：；骜察筠秘的稳定性、转篮法考察乳捌释敲特性。熬粜；制胬的摹L剂 体外累积释皴烂谯30b漆恁毗。6篱，其趣他饿矮殿稳定性均符念《巾牮A瓣菸霸翔魏熊》对静脉乳荆的甏求。缝 论：涮鍪的乳铡性敝稳定，钵外释麴驻蕊黧褥～宓鹊缓鞣作翊。为避…步瀚瀚褥及畹寐研究奠绽了然勰。 侮外释琴 美键溺；2-翠辍鏊雌=静；辫脉乳刹；理化髋质{ Pharmaceuticalof 2-methoxyestradiol Properties LntravenousEmnlsions ZHANG己衲崴LU Zhcnquan Hongyu，ZHANG of 450001) (School university,Zh孵hou Pharmacy，Zhengzhou To the andtherelease stability Abstract：Objectiveinvestigatephysicochemicalproperties，the invitroof intravenousemulsionsandevaluate chamctcm 2-methoxyestradiol i谯Q．ality．Methods intravenous andthe ofemulsions 2-methoxyesrradiolemuhions、^憾他preparedproperties including mead factorandaccumulativereleasewerestudied．Results翔e diameter,pH。viscosity，influential ratiooftheemulsion reached92。6％andThecmulsions cumulativedissolution prepared prepared and welrecoincidentwiththeChinese werestable prepared Pharmacopoeia。Conclusion羽艟emulsions itS invitroshowedslow-release establisha foundationforthe dissolution effect,which good ofanimal andclinicalresearch． development