手术病人中罗哌卡因的药代动力学研讨.pdfVIP

手术病人中罗哌卡因的药代动力学研究 Evaluation of pharmacokinetics of Ropivacaine in operational patients 徐红蓉 陈伟力 李雪宁 复旦大学附属中山医院临床药理室 上海 200032 XU Hong-Rong CHEN Wei-Li LI Xue-Ning Department of Clinical Pharmacology Zhong Shan Hospital Fudan University Shanghai 200032 摘 要 目的 对单剂量用罗哌卡因硬膜外麻醉的手术病人药代动力学特征进行研究 方法 选 择 12 例手术病人 硬膜外麻醉时 注入罗哌卡因 150mg 血药浓度用反相高效液相色谱法测定 用 3p97 药代动力学计算程序拟合房室模型并计算药代动力学参数 结果 罗哌卡因在手术病人中的代谢 -1 符合开放性二室模型 主要的药代动力学参数 tmax 为 0.27±0.10h Cmax 为 1.86±0.40 mg·L t1/2 á - 1 为 0.23±0.14h t1/2 â 为 2.17±0.55h AUC 为 4.84±1.20 mg·L ·h 结论 由手术病人硬膜外注射罗哌 卡因所得的药代参数可知 本实验所得的 t1/2 与文献报道健康志愿者的半衰期基本无变化 提示罗哌 卡因在体内的消除不受疾病的影响 关键词 罗哌卡因 药代动力学 高效液相色谱法 Abstract OBJECTIVE: To evaluate the pharmacokinetics characteristics of epidural ropivacaine in operational patients. METHODS: Ropivacaine 150mg were given to 12 patients as an epidural infusion for 4h. Ropivacaine concentration in plasma were determined by HPLC method. Pharmacokinetic parameters were calculated by 3P97 software. RESULTS: The mean concentration –time curve were fitted to two-compartment model. The main pharmacokinetic parameters were as follow: T were 0.27±0.10h max -1 -1 - 1 Cmax were 1.86±0.40 mg·L T1/2 á were 0.23±0.14h T1/2 â were 2.17±0.55h AUCwere 4.84±1.20 mg·L ·h . CONCLUSION: From the pharmacokinetics parameter s of epidural ropivacaine in operational patients, we can conclude that there was no sign