中性粒细胞计数淋巴细胞比值与晚期非小细胞肺癌临床病理关系及其在化疗中的意义.docVIP

精品论文 参考文献 中性粒细胞计数淋巴细胞比值与晚期非小细胞肺癌临床病理关系及其在化疗中的意义 韩军 胡宏燕 　　（安徽医科大学附属六安医院lt;六安市人民医院gt;呼吸内科 237005） 　　【摘要】 目的：探讨中性粒细胞计数/淋巴细胞比值（NLR）与晚期非小细胞肺癌（NSCLC）临床病理特征的关系，评价其对化疗的意义。方法：回顾性分析84例晚期NSCLC临床病理资料，以NLR均值为临界值，将患者分为低NLR组和高NLR组，分析NLR与NSCLC临床病理特征关系及 NLR化疗前后的变化。结果：NLR与肺癌病理分期、ECOG评分、血小板计数、血小板计数/淋巴细胞比值（PLR）有统计学差异（Plt;0.05），与性别、年龄、吸烟史、病理类型、血红蛋白(hgb)无统计学差异（Pgt;0.05）；NLR值化疗前4.11plusmn;2.94与化疗后3.04plusmn;2.55之间的差异有统计学意义（Plt;0.005）。结论： NSCLC患者病理分期越晚，NLR值越高； 化疗后NRL值的降低对化疗评价有参考意义。 　　【关键词】 中性粒细胞计数/淋巴细胞比值；非小细胞肺癌；化疗 　　【中图分类号】R730.2 【文献标识码】A 【文章编号】2095-1752（2015）23-0060-03 　　The relationship between neutrophil count/ lymphocyte ratio with advanced non-small cell lung cancer pathology and its significance in chemotherapy 　　 Han Jun, Hu Hongyan. Luan Affiliated Hospital, Anhui Medical University( Luan people hospital) , Anhui Province. Luan 237005, China 　　【Abstarct】 Objectiv To explore the relationship between neutrophil count/lymphocyte ratio (NLR) with advanced non-small cell lung cancer (NSCLC) clinical and pathological features,and to evaluate the significance of chemotherapy.Methods Retrospective analysis of 84 patients with advanced NSCLC clinical data，the patients were classified into two groups:low and high NLR group by the mean NLR as critical value, and then the association between NLR and clinicopathological features of NSCLC was analyzed. Result NLR with lung cancer staging, ECOG score, platelet count, platelet count/lymphocyte ratio (PLR) were significantly different (Plt;0.05), but not with gender, age, smoking history, histological type(Pgt;0.05); NLR value of the difference between before and after chemotherapy was statistically significant (4.11plusmn;2.94 and 3.04plusmn;2.55, respectively;P lt;0.005).Conclusion The later stage NSCLC patients with pathology, NLR value higher；there were reference significance of evaluation of chemotherapy by NRL value reduced after chemotherapy 　　【Key words】 Neutrophil count/-lymphocyte ratio; Non-small