凯时用于断指再植术后血管危象防治的临床研究.docVIP

精品论文 参考文献 凯时用于断指再植术后血管危象防治的临床研究 戎晓敏 李俊 　　（广东省广州市孙逸仙纪念医院 510275） 　　【摘要】目的 凯时（前列腺素E1）在手足外科中用于断指再植术后预防血管危象的临床效果。方法 我科86例112指断指再植病例，随机分为两组，对照组给予常规治疗，实验组在常规治疗的基础上使用凯时。对两组患者术后血管危象发生率、凝血功能及血液流变学进行统计分析，比较两组疗效。结果　与对照组相比，实验组血管危象发生率低，血液粘度降低，两组凝血功能无明显差别。讨论 凯时用于断指再植手术，能够预防血栓形成，降低血管危象的发生率，有较好的临床应用价值。 　　【关键词】 凯时 前列腺素E1 血管危象 断指再植 　　【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752（2014）06-0115-03 　　 　　Clinical study of alprostadil injection for the prevention and treatment for vascular crisis after severed fingers replantation. 　　Rong xiao-min*, Li jun *Department of pharmacy, Sun Yat ndash;Sen Memorial Hospital,Sun Yat-Sen University guangzhou 510120, China. 　　【Abstract】Object：to explore the effect of alprostadil injection used for the prevention of vascular crisis after replantation of severed fingers. Method：86 patients with 112 replanted fingers were randomly devided into 2 groups. The control group was given conventional treatment and the patients in treatment group were given alprostadil injection besides the conventional treatment. The incidence of vascular crisis, the coagulation function and blood rheology were analyze to evaluate the curative effect. Result：Compared with the control group，the treatment group was with low incidence of vascular crisis and reduce blood viscosity. The coagulation function was no significant difference between the 2 groups. Conclusion：It suggests thar in the finger replantation surgery, the alprostadil was of great clinical value for its prevention of thrombosis and reduction of the vascular crisis. 　　【Key words】 alprostadil injection prostaglandin E1 vascular crisis finger replantation 　　临床中，对于手指重度创伤、离断等尽早实施再植手术，是挽救创伤手指、恢复手指运动功能的关键。断指再植的成功与否，首先在于血管的吻合是否通畅。在强调精准的小血管吻合技术的同时控制预防血管栓塞，是预防血管危象、提高显微外科手术成功率的关键[1]。凯时（前列腺素E1），具有扩张血管、改善微循环的作用，临床中常用于动脉闭塞症、脏器移植术后抗血栓、先天性心脏病、肝炎等疾病的治疗[2，3]。本研究回顾性分析两种治疗方法的效果，说明前列腺素E1对断指再植术后血管危象的防治作用。 　　1.资料与方法 　　1.1临床资料：我科2011年10月～2013年10月共收治断指再植病例86例112指，男65例84指，女21例28指，年龄范