南蛇藤合剂对强直性脊柱炎的生活质量影响和疗效评价.docVIP

精品论文 参考文献 南蛇藤合剂对强直性脊柱炎的生活质量影响和疗效评价 解放军第一八一医院，广西桂林 541002 作者简介：戴小良，女，湖南长沙，博士，副主任医师，研究方向：风湿病的防治。 通讯作者：蒋文英，女，江苏常州，大学本科，护士长，副主任护师，从事临床护理工作30年 [摘要]目的 观察南蛇藤合剂对强直性脊柱炎(AS)患者的生活质量影响和并对其疗效进行评价。方法 84例AS患者按1：1比例随机分为南蛇藤合剂组(NST)和柳氮磺吡啶(sulfasalazine，SASP)组，分别服用南蛇藤合剂1付/d、SASP 2.0g/d，疗程1年，分别在治疗前和治疗后3、6、12个月记录患者症状、体征、AS活动指数(BASDAI)、应用SF-36量表来评价生活质量。结果 NST组有效率为88．2％，SASP组的总有效率为80.95%，在总体效果方面虽然无明显差异，均能明显控制患者疼痛关节数、腰痛晨僵时间、扩胸度、指地距离、Schober试验、ESR、CRP、BASDAI等临床症状，生活质量综合评分PCS和MCS均明显改善，但南蛇藤在改善患者腰痛晨僵症状和降低指地距离、ESR和CRP方面明显优于SASP。结论 南蛇藤合剂和SASP均能明显改善AS患者临床症状，提高生活质量，在一定程度上南蛇藤合剂优于柳氮磺吡啶。 关键词:南蛇藤；强直性脊柱炎；生活质量；影响；疗效评价 【中图分类号】R346【文献标识码】A【文章编号】1001-5213(2016)08-0248-02 [Abstract] Objective To observe Celastrus orbiculatus Thunb mixture quality of life in patients with ankylosing spondylitis (AS) and influence and to evaluate its efficacy. Methods 84 patients with AS according to the proportion of 1:1 were randomly divided into Celastrus orbiculatus Thunb mixture group (NST) and sulfasalazine (SASP) group, respectively taking Celastrus orbiculatus Thunb mixture 1dose/d, SASP 2.0 g/d , Course for one year, respectively before and after treatment for 3, 6, 12 months record patients symptoms, signs, AS activity index (BASDAI), the application of SF-36 scale to evaluate the quality of life.Results NST group effective rate was 88.2%, SASP group total effective rate was 80.95%, while no obvious difference in the overall effect, can significantly control number of joint pain, waist pain, morning stiffness time, chest expansion degree, refers to the distance, the Schober test, ESR, CRP, BASDAI and other clinical symptoms, life quality comprehensive score PCS and MCS were significantly improved, but Celastrus orbiculatus Thunb mixture to improve the symptoms of patients with waist pain, morning stiffness and lower refers to the distance, the ESR and CRP significantly better than that of SASP. Conclusion Celastrus orbiculatus Thunb mixture and SASP can obviously improve the AS patients with clinical symptoms,