原发性胆囊癌65例临床病理分析.docVIP

精品论文 参考文献 原发性胆囊癌65例临床病理分析 　（武警四川省总队医院 病理科，乐山 614000） 　　[摘要] 目的 探讨原发性胆囊癌的临床病理特点。 方法 选取我院2008年1月—2015年12月间手术切除胆囊标本确诊的原发性胆囊癌65例。全部标本使用10%中性福尔马林固定，规范病理取材，常规石蜡包埋，常规HE染色，光镜观察。 结果 65例原发性胆囊癌中男12例，女53例，平均年龄72.1岁，其中腺癌57例，鳞癌4例，腺鳞癌2例，未分化癌2例。 结论 原发性胆囊癌多发生于中老年女性，与多种危险因素有关，其中胆囊结石、胆囊慢性炎症是最常见的危险因素。术前B超、CT检查及术中快速冷冻切片检查有助于早期诊断。治疗首选手术。预后与临床分期、淋巴结转移情况、病理分级及发病部位有关。 　　[关键词] 胆囊癌；原发性；临床；病理 　　Clinicopathologic analysis of 65 cases of primary gallbladder carcinomas 　　GAO Rong-mei,PENG Feng-xiang,LI Yong-chun,Chen zhu Department of pathology, Sichuan provincial corps hospital CAPF,leshan,614000,china 　　[Abstract] Objective To analyze the clinical and pathological features of primary gallbladder carcinomas. Method To collect 65 cases of primary gallbladder carcinomas in our hospital from January 2008 to December 2015. All cases were in 10% neutral formalin-fixed, pathologic samplings, paraffin-embedded sections, routine HE staining. Results A total of 65 cases patients with primary gallbladder carcinomas: 12 males, 53 females, average age of 72.1 years, and 57 patients showed adenocarcinoma, 4 patients showed squamous cell carcinoma, and 2 patients revealed adenosquamous carcinoma, undifferentiated carcinoma in 2 cases. Conclusions Primary gallbladder carcinomas often occurred in mid-aged and elderly women. The pathogenesis was associated with various risk factors. Gallbladder stones and chronic cholecystitis were the most common risk factors. B-ultrasound, CT examination and intraoperative frozen section are helpful for early diagnosis. At present surgical is principal for treatment. Prognosis is related to clinical stage, lymph node metastasis, pathological grade and the location of the carcinoma. 　　[Key words] Gallbladder carcinoma; Primary; Clinic; Pathology 　　原发性胆囊癌是胆道系统最常见的恶性肿瘤，我国发病率为4.97/10万[1]，位居胆道系统肿瘤第一位[2]。多发生于60岁以上，女性多见。近年来随着社会人口老龄化和健康检查的普及，发病率呈明显上升趋势。临床上原发性胆囊癌常缺乏特异性的临床表现，易与胆囊炎、胆囊结石等相互混淆，因此早期诊断困难，发现时多属于晚期，一般预后较差[3]。我们收集了我院确诊的65例原发性胆囊癌，对其临床病理特点进行分析。 　　1.资料和方法 　　1.1资料 　　选取我院2008