叶酸、维生素B6和甲钴胺降低H型高血压患者血浆同型半胱氨酸的效果评价.docVIP

精品论文 参考文献 叶酸、维生素B6和甲钴胺降低H型高血压患者血浆同型半胱氨酸的效果评价 夏锋 张静 奚齐红 陶海琦 孙丽艳 　　（上海市闸北区彭浦镇社区卫生服务中心 上海 200072） 　　【摘要】 目的：比较叶酸、维生素B6和甲钴胺降低H型高血压患者同型半胱氨酸的有效性和安全性差异，探讨更安全有效的预防H型高血压并发症的方案。方法：将252名H型高血压患者随机分为3组，每组84例，分别应用叶酸、维生素B6和甲钴胺治疗6个月，比较3组间同型半胱氨酸降低的差异。结果：有效性方面，叶酸组和甲钴胺组有效率分别为88.89%和86.71%，两组比较差异无统计学意义（P＞0.05），维生素B6组有效率为69.44%，差异有统计学意义（P＜0.05）；安全性方面，叶酸组、甲钴胺组、维生素B6组不良反应发生率分别为0%、6.75%和16.27%，各组比较差异有统计学意义（P＜0.05）。结论：从有效性、安全性和社会经济性综合分析，叶酸降低H型高血压患者同型半胱氨酸效果优于维生素B6和甲钴胺。 　　【关键词】 叶酸；维生素B6；甲钴胺；H型高血压；同型半胱氨酸；效果分析 　　【中图分类号】R544.1 【文献标识码】A 【文章编号】2095-1752（2016）11-0188-02 　　Comparison among vitamin therapy ( folic acid, vitamin B12, and B6) on lowering plasmahomocysteinein patients with H-type hypertension XIA Feng,ZHANG Jing, XI Qihong,TAO Haiqi, SUN Liyan Pengpu town community health service center of Zhabei District,Shanghai200072,China 　　【Abstract】Objective Comparing the differences in efficacy and safety among folic acid, vitamin B6, and vitamin B12 reduced the level of homocysteine of the patients with H-type hypertension,to explore the safer and more effective treatment of H-type hypertension.Methods 252 patients with H-type hypertension were randomly divided into 3 groups, each group of 84 cases were observed among the three groups respectively using folic acid, vitamin B6 and Mecobalamine Injection to reduce the effect of homocysteine.Results effectiveness, folic acid group and Mecobalamin group rate was 88.89% and 86.71% respectively, the difference between the two groups no significant (Pgt;0.05), vitamin B6, efficiency is 69.44%, the difference was statistically significant (P lt; 0.05); safety, folic acid group, Mecobalamin group, vitamin B6 adverse reactions of the two groups occurred rate of 0%, 6.75% and 16.27% respectively, the difference among the three groups have statistical significance (Plt;0.05).Conclusion comprehensive analysis From the perspective of the effectiveness, safety and social economy, folic acid to reduce the level o