妊高症肾病患者血浆ET-1和血清CYSC、NPY和SOD水平检测的临床意义.docVIP

精品论文 参考文献 妊高症肾病患者血浆ET-1和血清CYSC、NPY和SOD水平检测的临床意义 孙璐 　　（江苏省沭阳县中医院妇产科 223600） 　　【摘要】目的 探讨了妊高症肾病患者血浆ET-1和血清CYSC、NPY和SOD水平检测的临床意义。方法 应用放射免疫分析法和乳胶免疫增强比浊法对31例妊高症肾病患者进行了血浆ET-1和血清CYSC、NPY和SOD水平检测，并与35名正常健康人体比较。结果 妊高症肾病患者血浆ET-1和血清CYSC、NPY和SOD水平均非常显著地高于正常人组（Plt;0.01），而SOD水平又非常显著地低于正常人组（Plt;0.01），血清SOD水平与ET-1、CYSC、NPY水平呈显著负相关（r=-0.4782-0.5019-0.6024 .Plt;0.01）。结论 检测妊高症肾病患者血浆ET-1和血清CYSC、NPY和SOD水平的变化对了解病情、观察预后有重要的临床价值。 　　【关键词】妊高症，肾病，内皮素-1，胱抑素C,神经肽Y,超氧化物歧化酶 　　【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2014）03-0064-02 　　Clinical Significance of measurement of Changes of changes of plasma ET-1 and Serum CYSC、NPY and SOD Levels in patients with pregnancy induced hypertension Complicated with Nephropathy. 　　【Abstract】Objective :To explore the clinical Significance of changes of plasma ET-1 and Serum CYSC、NPY and SOD Levels in patients with pregnancy induced hypertension(PIH) Complicated with Nephropathy.Nephropathy 　　Methods : plasma ET-1 and Serum NPY 、 SOD（with RIA） 、Serum CYSC(with latex enhanced imnchoturb Idimetry assay)levels were determined in 31 patients with PIH complicated with Nephropathy and 35 controls. 　　Result :The plasma ET-1 、CYSC、NPY Levels were significantly higher in the patients than those in contrils(Plt;0.01),but Serum SOD levels were significantly lower than those in contrils(Plt;0.01), Serum SOD levels were negatively correlated with ET-1、CYSC、NYP levels (r=-0.4782-0.5019-0.6024 .Plt;0.01). 　　Conclusions: Detection of plasma ET-1 and Serum NPY 、 SOD levels might be of prognostic importance in patients with PIH complicated with Nephropathy. 　　【Key words】pregnancy induced hypertension (PIH) Nephropathy Endothelin-1(ET-1) Cystatin C(CYSC) Neusopeptide Y (NPY) Superoxide dismutase (SOD) 　　妊高症为妇产科的常见病、多发病，如不及时诊治将会发生严重的并发症，其中以肾脏损伤最为多见。ET-1是血管内皮细胞分泌的缩血管多肽，是迄今为止发现的血管收缩功能最强的内源性物质。CYSC为早期诊断肾小球损失的一个敏感指标。NYP存在于人和多数动物的肾脏，即可以通过交感神经节的核团转移到肾脏，也可以在肾脏局部形成，故肾血管如肾小管周围含有丰富的NPY。近年的研究证实：SOD水平检测与肾的关系密切，广泛受到临床和科研工作者关注。国内尚