醋制紫硇砂最佳炮制工艺研究-天津中草药杂志社.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 1 期 2014 年 1 月 ·55 · 醋制紫硇砂最佳炮制工艺研究 1 1 1 1, 2* 毛春芹 ，季 德 ，陈 强 ，陆兔林 1. 南京中医药大学药学院，江苏 南京 210023 2. 南京中医药大学 江苏省中药炮制重点实验室，江苏 南京 210023 摘 要：目的 优选醋制紫硇砂最佳炮制工艺。方法 以小鼠耳肿胀抑制率、半数致死量（LD50 ）和氯化钠质量分数作为指 标，选择加水量、醋用量、粒度及析晶时间 4 个因素，用 L 4 9(3 ) 正交设计表，采用方差分析，对紫硇砂醋制工艺进行优选。 结果 醋制紫硇砂最佳炮制工艺为选择过 40 目筛的紫硇砂，加5 倍量水，加饮片总量 50%的醋，控制析晶时间为 60 min 。 结论 该工艺设计合理，稳定可靠，为醋制紫硇砂的质量控制奠定了基础。 关键词：紫硇砂；醋制；正交试验；耳肿胀抑制率；半数致死量 中图分类号：R283.1 文献标志码：A 文章编号：0253 - 2670(2014)01 - 0055 - 04 DOI: 10.7501/j.issn.0253-2670.2014.01.011 Optimal processing technique of vinegar-processed Halite Violaceous 1 1 1 1, 2 MAO Chun-qin , JI De , CHEN Qiang , LU Tu-lin 1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China 2. Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China Abstract: Objective To optimize the processing technique for vinegar-processed Halite Violaceous. Methods The ear swelling, median lethal dose (LD50), and content of sodium chloride were chosen as indicators, the optimal technique was investigated by the factors of water amount, vinegar amount, particle size, and crystallization time, and determined by L 4 9(3 ) orthogonal test and varience analysis. Results The optimal processing conditions were as follows: using 40 mesh to screen Helite Violaceous, adding the amount of water in five times, and 50% of the total increase vinegar as total amount as pieces, and controlling the crystallization time to 60 min. Conclusion The processing technology is reasonable, stable, and feasible, which could lay a s