缓激肽离子通道与炎症性疼痛Bradykininmodulatesion-药学学报.PDFVIP

See discussions, stats, and author profiles for this publication at: /publication Bradykinin modulates ion channel in inflammatory pain Article in ao xue xue bao = Acta pharmaceutica Sinica · October 2009 Source: PubMed CITATION READS 1 119 2 authors, including: Hailin Zhang Hebei Medical University 183 PUBLICATIONS 4, 43 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: Gating mechanism and structural basis of Kir channels. View project All content following this page was uploaded by Hailin Zhang on 05 August 2014. The user has requested enhancement of the downloaded file. 1066 药学学报 Acta Pharmaceutica Sinica 2009, 44 ( 10) : 1066 1071 缓激肽、离子通道与炎症性疼痛 刘伯一, 张海林* (河北医科大学基础医学院药理学教研室, 河北 石家庄 050017) 摘要: 机体损伤或发生炎症时, 受损或者发炎的组织释放诸多炎症介导因子。缓激肽是一种重要的炎症介导 因子, 在介导炎症性疼痛方面发挥重要作用。众所周知, 痛觉的产生依赖于痛觉感受器表面分布的诸多离子通道 的参与。近年来的研究显示, 缓激肽在调控这些痛觉相关离子通道的功能与表达方面发挥重要作用, 因此本文就 缓激肽对痛觉相关离子通道调控作用的研究进展进行总结, 并探讨治疗炎症性疼痛的未来方向。 关键词: 缓激肽; 离子通道; 炎症性疼痛 中图分类号: R963 文献标识码:A 文章编号: 05 13-4870 (2009) 10-1066-06 Bradykinin modulates ion channel in inflammatory pain * LIU Bo-yi, ZHANG Hai-lin (Depa rtment of Pharmacology, School of Basic Medicine, Hebei Medical University, Shij iazhuang 050017, China) Abstract: Injury or inflammation induces release of a range of inflammatory mediators. Bradykinin is one of the most important inflammatory mediators and pla