二甲双胍对乙型糖尿病患者血HS-CRPTNF-ΑICAM1水平的影响.DOCVIP

二甲双胍对2型糖尿病患者血HS-CRP、TNF-αICAM-1水平的影响 卢薇 欧亚萍 梁英梅 [摘要] 目的：观察二甲双胍治疗前后2型糖尿病患者(T2DM)血清高敏C反应蛋白（HS-CRP）、肿瘤坏死因子α(TNFα）、和细胞间粘附分子1（ICAM-1）水平变化，探讨二甲双胍与炎症因子的关系。方法：选择42例2型糖尿病患者，测定二甲双胍治疗前后血清HS- CRP，TNF-α、ICAM-1水平并与30例正常人进行对比分析。结果，T2DM血清HS-CRP、TNF-α、ICAM-1浓度较正常人升高，差异显著（p＜0.01），且二甲双胍治疗8周后血清HS-CRP、TNF-α、ICAM-1水平明显降低（P＜0.01）。结论：2型糖尿病患者存在炎症活动，二甲双胍在降低血糖的同时有抗炎作用，能使炎症因子水平明显降低。 关键词：二甲双胍 高敏C-反应蛋白（HS-CRP） 肿瘤坏死因子-α（TNF-α） 细胞间粘附分子-1（ICAM-1） 2型糖尿病 Observation on the effect of metformin on high-sensitive c-reactive protein, tumor necrosis factor-α and intercellular adhesion molecule-1 in type 2 diabetes mellitus. Lu Wei ,OuYa-ping, Liang Ying-mei. The Second People’s Hospital of Gui Yang ,Gui Yang 550002, Gui Zhou ,China [Abstract] objective： To investigate the effect of metformin on high-sensitive c-reactive protein (HS-CRP), tumor necrosis factor-α (TNF-α) ,amd intercellular adhesion molecule-1(ICAM-1) in type 2 diabetes mellitus (T2DM). Methods ： 42 newly diagnosed type 2 diabetes and 30 healthy people were selected and divided into two groups :T2DM groups and control groups. In T2DM group, metformin (0.5g Tid)were taken for 8 weeks .The serum HS-CRP 、TNF-αand ICAM-1 level were measured with Elisa before and after the treatment .The levels in T2DM compared to control groups. Results compared with control group ,T2DM showed the higher levels of HS-CRP. TNF-αand ICAM-1. And after 8 weeks of metformin treatment T2DM showed the lower levels of HS-CRP、TNF-αand ICAM-1 (all P＜0.01).Conclusions Inflammation play aimportant role in T2DM. Metformin can decrease the levels of inflammation factors in T2DM. [Key words] metformin c-reactive protein tumor necrosis factor-α intercellular adhesion molecule-1 type 2 diabetes mellitus 严格控制血糖可以明显降低糖尿病患者微血管病变的发生率，但没有显著降低大血管病变的病死率，原因尚不清楚，近年来越来越多的临床和实验室资料证明，炎症可能是2型糖尿病和动脉粥样硬化的共同土壤。为了解2型糖尿病与慢性炎症的关系及二甲双胍对其干预作用故选择42例2型糖尿病患者测定二甲双胍治疗前及治疗8周后的血清HS-CRP、TNF-α、ICAM-1水平并与正常人进行对比分析，探讨其临床意义。 1对象方法 1.1对象 收集本院内科住院患者42例，其中男23例，女19例，年龄38-73岁，平均54.5±7.