基于物质粗糙集理论的中药复方缓释制剂总量释放动力学评价模式.DOCVIP

基于物质粗糙集理论的中药复方缓释制剂“总量”释放动力学评价模式 岳鹏飞, 郑琴, 杨明(江西中医学院现代中药制剂教育部重点实验室, 江西 南昌 330004) 摘要: 中药复方缓控释制剂体外释放动力学评价研究是中药制剂现代化研究中不可分割的重要组成部分, 在现代复方中药研发中发挥着重要作用, 但目前尚缺乏符合中药自身多成分多靶点特征的释放动力学评价方法。本文在回顾分析既有评价模式利弊的基础上, 借鉴粗糙集理论, 提出基于物质粗糙集理论的中药复方缓释制剂“总量”释放动力学评价模式, 评价释放过程中复方中药制剂的化学物质“总量”动态变化特征, 以期“抛砖引玉”, 促进中药复方缓控释制剂释放行为评价方法的发展。 粗糙集理论; “总量”释放动力学; 多元校正计量; 效应计量; 中药缓释制剂A 文章编号: 0513-4870 (2010) 11-1354-07 “Total amount” release kinetics evaluation of traditional Chinese medicine sustained-release preparations based on material rough set theory YUE Peng-fei, ZHENG Qin, ZHU Gen-hua, WU Zhen-feng, HU Peng-yi, YANG Ming* (Key Lab of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China) Abstract: The release kinetics research of sustained-release formulations of traditional Chinese medicines (TCM) is an inalienable part of the chain of TCM modernization, which plays an important role in the development of modern compound TCM preparation. However, the research method or pattern in line with the specific characteristics of TCM, i.e., multi-component and multi-target, is still lacking. On the basis of material rough set theory, this paper reviewed the advantages and disadvantages of the existing evaluation patterns and methods, a tentative idea about the “total amount” release characteristics evaluation on TCM compound sustained-release preparation has suggested so as to evaluate the release kinetics and to promote the development of evaluation methodology on TCM sustained-release preparations. Key words: rough set theory; “total amount” release kinetics; multivariate calibration metrics; bioactivity metrics; TCM sustained-release preparation (缓释制剂体外释放行为评价是缓控释剂型设计、处方工艺优化与质量控制的基本手段。与化药相比, 由于中药及其复方制剂多成分和整体性的 特点, 套用化学制剂评价方法无法体现中药复方制剂释放过程中化学物质的全息特征, 不能评价中药多组分释放的同步性与整体性,对设计中药缓控释制剂的指导性意义不强[1?3]