对比丙硫氧嘧啶与甲巯咪唑治疗Graves病对肝功能的影响.docVIP

精品论文 参考文献 对比丙硫氧嘧啶与甲巯咪唑治疗Graves病对肝功能的影响 江苏省原子医学研究所附属江原医院 214063 【摘要】目的 对比丙硫氧嘧啶与甲巯咪唑治疗Graves病对肝功能的影响及疗效，为临床治疗提供参考。方法 选取2014年5月到2015年2月在我院诊断为Graves病患者86例为观察对象，选取白细胞3.5~4.5times;109/L，中性粒细胞1.5~2.0times;109/L予丙硫氧嘧啶治疗的患者43例，定为A组。选取同期白细胞gt;4.5times;109/L，中性粒细胞gt;2.0times;109/L予甲巯咪唑治疗的患者43例，为B组，要求与A组年龄、性别、病情严重程度相匹配。治疗6月对比两组肝功能指标。结果 A组患者出现肝功能损害13例（30.23%），B组4例（9.3%）（Plt;0.05）。A组肝功能损害发生时间为1.27月，B组患者0.625月。A组治疗后主要是转氨酶上升，占84.61%；B组主要是胆红素上升，占75%，两组患者治疗均有较好疗效。结论 丙硫氧嘧啶与甲巯咪唑治疗Graves病均有疗效，丙硫氧嘧啶对肝功能的损害机率更大，甲巯咪唑引起肝功能损害的时间更早，都值得引起重视，服药期间需定期检查肝功能，及时给予保肝治疗。 【关键词】丙硫氧嘧啶；甲巯咪唑；Graves病；肝功能 Comparison of the efficacy of propylthiouracil and methimazole treatment of Graves disease on liver function [Abstract]Objective The impact on liver function and curative effect of propylthiouracil and methimazole treatment of Graves disease，to provide reference for clinical treatment..Methods From May 2014 to February 2015，86 patients with Graves disease were treated in our hospital from to.Selection of white blood cell 3.5~4.5times;109/L，neutrophil 1.5~2.0times;109/L give propylthiouracil therapy for patients with 43 cases，as group A，Select the same period blood white cells gt;4.5times;109/L，neutrophils were higher than gt;2.0times;109/L，giving methimazole treatment in patients with Graves disease 43，as group B，requirements and a group of patients with age，gender，severity of phase matching.Liver function index of the two groups were compared in six months.Results 13 cases（30.23%）of liver function damage in group A，4 cases（9.3%）in group B.The patients with liver function damage in group A were within 1.27 months，within 0.625 months of group B.After treatment，group A was increased by 84.61%.In group B，the bilirubin increased，accounting for 75%.Two groups of patients were treated with better curative effect Conclusion Propylthiouracil and methimazole treatment of Graves disease has the curative effect and propylthiouracil on liver function damage more likely，methimazole induced liver function impairment o