帕瑞昔布超前镇痛在门诊无痛膀胱镜检查中的应用.docVIP

精品论文 参考文献 帕瑞昔布超前镇痛在门诊无痛膀胱镜检查中的应用 南京医科大学第二附属医院 麻醉科 210011 【摘 要】目的 探讨帕瑞昔布超前镇痛在门诊无痛膀胱镜检查中的应用效果。方法 选择100例行无痛膀胱镜检查的患者，随机分为两组：单纯丙泊酚组（N组）和帕瑞昔布＋丙泊酚组（P组），每组50例。麻醉诱导前15min静脉注射帕瑞昔布钠加40mg和相同体积的生理盐水5ml。随后静脉推注丙泊酚，并在术中视患者麻醉情况适量追加。记录麻醉诱导时间、膀胱镜检查时间、丙泊酚用量、术后苏醒时间；记录HR、MAP、SpO2等生命体征的变化；记录术中体动反应、呼吸暂停、低氧血症、心动过缓、低血压、注射痛及术后有关并发症的发生情况。结果 与N组相比，P组的丙泊酚用量减少（Plt;0.05）；低氧血症、低血压和呼吸暂停的发生率明显降低（Plt;0.05）。结论 帕瑞昔布在门诊无痛膀胱镜检查中具有良好的镇痛效果，并可有效降低不良反应发生率。 【关键词】帕瑞昔布钠；无痛膀胱镜；丙泊酚 Efficacy of Parecoxib in Painless Cystoscopy through preemptive analgesia.Peng Hui，Zhang Qing，Chen Hui-yu，Hu Bin.Department of Anesthesia，Second Affiliated Hospital of Nanjing Medical University，Nanjing 210011，China [Abstract] Objective To evaluate the effects of Parecoxib for preemptive analgesia in Ptients undergoing Pinless Cystoscopy.MethodsIn a double-blind study，100 Patients o were randomized into 2 group6（n=50 each）：Propofol group（group N）and Parecoxib combine with Propofol group（group P）．In group N，Parecoxib 40 mg in 5 ml of normal saline（N）was injectecl iv over 15 min before induction of anesthesia．In group N 5 ml Was injected instead of Parecoxib．Propofol was injected iv at 1ml//6s until disappearance of eyelash reflect.Cystoscopy was performed．The Ptients were breathing spontaneously．Oxygen was administered via face mask．Additional propofol was given according to the Patients respone to surgical stimuli．HR，MAP，SpO2，anesthesia induction time，Cystoscopy time，the amount of propofol administered and recovery time were recorded．In addition intraoperative body movement，apnea，hypoxemia，bradycardia，hypoteNion，injection Pin and postoperative complication were also recorded.Results Compared with group N，the amount of propofol administered is fewer（Plt;0.05）and the incidences of intraoperative apnea，hypoxemia，hypotension，is lower（Plt;0.05）.Conclusion Intravenous Parecoxib has good effect.Besides that，the incidences of intra-and post-operative complication were lower. [Key words] Parecoxib；Painless Cystoscopy；Propofol