替加环素与碳青霉烯类抗生素治疗多重耐药鲍曼不动杆菌感染疗效比较.pdfVIP

第21 卷2 期 天津医科大学学报 Vol． 21, No． 2 164 2015 年3 月 Journal of Tianjin Medical University Mar． 2015 （ ） 文章编号 1006－8147 2015 02-0164-04 论 著 替加环素与碳青霉烯类抗生素治疗多重耐药鲍曼不动 杆菌感染疗效比较 1 2 2 张德林 ，李忠廉 ，张西波 （1.天津医科大学研究生院， 天津300070；2.天津市南开医院肝胆外科，天津300100） 摘要 目的： 观察替加环素治疗多重耐药鲍曼不动杆菌（MDRAB）感染的临床疗效。方法：选取78 例腹腔手术术后发生多重耐 药鲍曼不动杆菌感染的临床病例作为观察对象，分为碳青霉烯类抗生素组（A 组）40 例、替加环素组（B 组）38 例；治疗疗程平均 2 周。每组患者在年龄、性别、基础疾病等方面差异无统计学意义。观察2 组患者的细菌学疗效、临床疗效的变化以及安全性评 价。结果：A 组临床有效率57.50% ，细菌清除率52.50% ；B 组临床有效率71.05% ，细菌清除率68.42％ ，A、B 两组组间比较、组内 比较差异有统计学意义（P0.05）。两组均未出现严重不良反应。结论:替加环素对MDRAB 导致感染具有良好的临床疗效及安全 性，可作为此类细菌感染临床用药的选择。 关键词 替加环素；多重耐药鲍曼不动杆菌；抗菌药物；腹腔感染 中图分类号 R63 文献标志码 A Comparsion of clinical effects between tigecycline and carbapenems in treatment of infections caused by multidrugresistant Acinetobacter baumannii 1 2 2 ZHANG De-lin ，LI Zhong-lian ，ZHANG Xi-bo (1.Graduate School, Tianjin Medical University ，Tianjin 300070 ，China；2．Department of Hepatobiliary Surgery ，Tianjin Nankai Hospi－ tal ，Tianjin 300100 ，China) Abstract Objective ：To observe the clinical efficacy of tigecycline in treatment of infections caused by multidrugresistant acinetobacter baumannii. Methods: A total of 78 cases of abdominal infections caused by multidrugresistant Acinetobacter baumannii were retrospectively studied.The patients were divided into the carbapenems group (group A) of 40 cases and the tigecycline group (group B) of 38 cases. The course were about 2 weeks on average. There were no statistical difference in the age, gender, or underlying diseases between the two groups. The bacteriological effect, the therapeutic effect and safety evaluation were observed and compared between the two groups. Results: The