Optical coherence tomography Technology and applications for neuroimaging英文电子书.pdfVIP

Psychophysiology, 40 (2003), 529–541. Blackwell Publishing Inc. Printed in the USA. Copyright r 2003 Society for Psychophysiological Research Optical coherence tomography: Technology and applications for neuroimaging STEPHEN A. BOPPART Department of Electrical and Computer Engineering, Bioengineering Program, and Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana–Champaign, Urbana, Illinois, USA Abstract Optical coherence tomography (OCT) is an emerging imaging technology with applications in biology, medicine, and materials investigations. Attractive features include high cellular-level resolution, real-time acquisition rates, and spectroscopic feature extraction in a compact noninvasive instrument. OCTcan perform ‘‘optical biopsies’’ of tissue, producing images approaching the resolution of histology without having to resect and histologically process tissue specimens for characterization and diagnosis. This article will review several of the current technological developments in OCT. To illustrate the potential of this technology for neuroimaging, applications for imaging neural development, the neural retina, tumors of the central nervous system, and the microsurgical repair of peripheral nerves will be presented. This technology offers a potential investigative tool for addressing many of the present challenges in neuroimaging. Descriptors: Imaging, Optics, Spectroscopy, Optical coherence tomography In recent years, biomedical imaging technology has made rapid rather than sound. OCT offers noninvasive real-time, high- advances that enable the visualization, quantification, and resolution imaging of cell and tissue microstructure deep within monitoring of morphology and function. New technologies have highly scattering tissues. Although OCT has been demonstrated pushed the limits of imaging fr